fam19a1
Danio rerio
Gene Name: family with sequence similarity 19 member A2, C-C motif chemokine like
Aliases: TAFA; FAM19A
Human Ortholog: FAM19A2
Aliases: TAFA; FAM19A
Human Ortholog: FAM19A2
Summary Statistics:
# of Reports: 1
# of Models: 1
# of Reports: 1
# of Models: 1
External Links
Model Summary
Sam2 knockout zebrafish ehxibit decreased socail behaviors but no change in locomotor activity.
References
Type
Title
Author, Year
Primary
Pharmacological (ethanol) and mutation (sam2 KO) induced impairment of novelty preference in zebrafish quantified using a new three-chamber social ...
Z_FAM19A1_1_KO_HM
Model Type:
Genetic
Model Genotype: Homozygous
Mutation: Target specific ZFN vectors for sam2 carrying capped ZFN mRNA were injected into one cell stage embryos (Choi et al., 2018).
Allele Type: Knockout
Strain of Origin: Unreported
Genetic Background: Unreported
ES Cell Line:
Mutant ES Cell Line:
Model Source: Choi et al., 2018 (PMID 29339520)
Model Genotype: Homozygous
Mutation: Target specific ZFN vectors for sam2 carrying capped ZFN mRNA were injected into one cell stage embryos (Choi et al., 2018).
Allele Type: Knockout
Strain of Origin: Unreported
Genetic Background: Unreported
ES Cell Line:
Mutant ES Cell Line:
Model Source: Choi et al., 2018 (PMID 29339520)
Z_FAM19A1_1_KO_HM
Category
Entity
Quantity
Experimental Paradigm
Age at Testing
Social memory1
Decreased
Description: Morphants showed a decrease in average duration of time spent in zone 5 closest to stimulus fish 2 during phase II (introduction of stimulus fish 2) compared to controls. Moreover, morphants showed no difference in distance from stimulus fish 1 or stimulus fish 2 during phase II compared to controls.
Three-chamber social approach test
9-12 months
Social approach1
Decreased
Description: Morphants showed a decrease in average duration of time spent in zone 1 closest to stimulus fish 1 during phase I (introduction of stimulus fish 1) compared to controls. However, morphants showed no change in the distance from stimulus fish 1 compared to controls.
Three-chamber social approach test
9-12 months
General locomotor activity: ambulatory activity1
No change
Three-chamber social approach test
9-12 months
Not Reported:
Circadian sleep/wake cycle, Communications, Developmental profile, Emotion, Immune response, Learning & memory, Maternal behavior, Molecular profile, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, Sensory