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No Human Gene Data Available
Chromosome
CNV Locus
CNV Type
# of studies
Animal Model
11
Deletion-Duplication
 23
 
11
Duplication
 1
 
11
Duplication
 1
 

Model Summary

Participation of dopamine receptor D4 in executive learning.

References

Type
Title
Author, Year
Primary
Reward-seeking and discrimination deficits displayed by hypodopaminergic mice are prevented in mice lacking dopamine D4 receptors.

M_DRD4_1_KO_HM

Model Type: Genetic
Model Genotype: Homozygous
Mutation: Targeted deletion of Drd4 gene.
Allele Type: Targeted (Knock Out)
Strain of Origin: CF-1
Genetic Background: Not Specified
ES Cell Line: Not Specified
Mutant ES Cell Line: Not Specified
Model Source: Not Specified

M_DRD4_1_KO_HM

Category
Entity
Quantity
Experimental Paradigm
Age at Testing
Reward reinforced choice behavior1
Increased
Description: Increased continous reinforcement demonstrated by increased rates of lever press after administration of 6-ohda
Exp Paradigm: Operant lever response for food pellet reward for continous reinforcement test after administraion of 6-ohda
 Operant conditioning paradigm
 Unreported
Reward reinforced choice behavior1
Increased
Description: Increased continous reinforcement demonstrated by increased rates of lever press
Exp Paradigm: Operant lever response for food pellet reward for continous reinforcement test
 Operant conditioning paradigm
 Unreported
Reward reinforced choice behavior1
 No change
 Operant conditioning paradigm
 Unreported
Reward reinforced choice behavior1
 No change
 Operant conditioning paradigm
 Unreported
 Not Reported: Circadian sleep/wake cycle, Communications, Developmental profile, Emotion, Immune response, Maternal behavior, Molecular profile, Motor phenotype, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, Sensory, Social behavior

 

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