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No Human Gene Data Available
Chromosome
CNV Locus
CNV Type
# of studies
Animal Model
11
Deletion-Duplication
 24
 
11
Duplication
 1
 
11
Duplication
 3
 

Model Summary

Participation of dopamine receptor D4 in executive learning.

References

Type
Title
Author, Year
Primary
Reward-seeking and discrimination deficits displayed by hypodopaminergic mice are prevented in mice lacking dopamine D4 receptors.

M_DRD4_1_KO_HM

Model Type: Genetic
Model Genotype: Homozygous
Mutation: Targeted deletion of Drd4 gene.
Allele Type: Targeted (Knock Out)
Strain of Origin: CF-1
Genetic Background: Not Specified
ES Cell Line: Not Specified
Mutant ES Cell Line: Not Specified
Model Source: Not Specified

M_DRD4_1_KO_HM

Category
Entity
Quantity
Experimental Paradigm
Age at Testing
Reward reinforced choice behavior1
Increased
Description: Increased continous reinforcement demonstrated by increased rates of lever press
Exp Paradigm: Operant lever response for food pellet reward for continous reinforcement test
 Operant conditioning paradigm
 Unreported
Reward reinforced choice behavior1
Increased
Description: Increased continous reinforcement demonstrated by increased rates of lever press after administration of 6-ohda
Exp Paradigm: Operant lever response for food pellet reward for continous reinforcement test after administraion of 6-ohda
 Operant conditioning paradigm
 Unreported
Reward reinforced choice behavior1
 No change
 Operant conditioning paradigm
 Unreported
Reward reinforced choice behavior1
 No change
 Operant conditioning paradigm
 Unreported
 Not Reported: Circadian sleep/wake cycle, Communications, Developmental profile, Emotion, Immune response, Maternal behavior, Molecular profile, Motor phenotype, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, Sensory, Social behavior

 

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