DPP10
Homo sapiens
Gene Name: Dipeptidyl-peptidase 10
Aliases: DPL2; DPPY; DPRP3
Chromosome No: 2
Chromosome Band: 2q14.1
Genetic Category: Rare Single Gene variant
Aliases: DPL2; DPPY; DPRP3
Chromosome No: 2
Chromosome Band: 2q14.1
Genetic Category: Rare Single Gene variant
Summary Statistics:
ASD Reports: 13
Recent Reports: 5
Annotated variants: 16
Associated CNVs: 3
Evidence score: 2
ASD Reports: 13
Recent Reports: 5
Annotated variants: 16
Associated CNVs: 3
Evidence score: 2
| Associated Disorders: |
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Relevance to Autism
Rare mutations in the DPP10 gene have been identified with autism (Marshall et al., 2008).
Molecular Function
Binds specific voltage-gated potassium channels and alters their expression and biophysical properties
External Links
References
Type
Title
Type of Disorder
Associated Disorders
Author, Year
Primary
Structural variation of chromosomes in autism spectrum disorder.
ASD
Negative Association
Use of clinical chromosomal microarray in Chinese patients with autism spectrum disorder-implications of a copy number variation involving DPP10.
ASD
Support
Mutations in Human Accelerated Regions Disrupt Cognition and Social Behavior.
ASD
Support
Refinement and discovery of new hotspots of copy-number variation associated with autism spectrum disorder.
ASD
Support
A discovery resource of rare copy number variations in individuals with autism spectrum disorder.
ASD
Highly Cited
Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10).
Recent Recommendation
Human-specific histone methylation signatures at transcription start sites in prefrontal neurons.
Recent Recommendation
Augmentation of Kv4.2-encoded currents by accessory dipeptidyl peptidase 6 and 10 subunits reflects selective cell surface Kv4.2 protein stabilizat...
Recent Recommendation
Weighing the evidence for a ternary protein complex mediating A-type K currents in neurons.
Recent Recommendation
Ternary Kv4.2 channels recapitulate voltage-dependent inactivation kinetics of A-type K channels in cerebellar granule neurons.
Recent Recommendation
DPP10 is an inactivation modulatory protein of Kv4.3 and Kv1.4.
