Cdk2
Drosophila melanogaster
Gene Name: cyclin dependent kinase 2
Aliases: cdc2c; Cdc2c; CDC2c; CDC2C; cdk2; CDK2; CDK2/CDC2c; CG10498; Dcdc2c; dCdk2; Dmcdc2c; DmCdc2c; DmCdk2; DmelCG10498; S(Sev-CycE)3A
Human Ortholog: CDK2
Aliases: cdc2c; Cdc2c; CDC2c; CDC2C; cdk2; CDK2; CDK2/CDC2c; CG10498; Dcdc2c; dCdk2; Dmcdc2c; DmCdc2c; DmCdk2; DmelCG10498; S(Sev-CycE)3A
Human Ortholog: CDK2
Summary Statistics:
# of Reports: 1
# of Models: 2
# of Reports: 1
# of Models: 2
External Links
Model Summary
Cdk2 mutant larvae showed aberrant innervation patterns of type III axons in muscle 13 (M13) neuromuscular junctions as well as significant downregulation of rl transcript expression.
References
Type
Title
Author, Year
Primary
MAPK3 at the Autism-Linked Human 16p11.2 Locus Influences Precise Synaptic Target Selection at Drosophila Larval Neuromuscular Junctions.
F_CDK2_1_KD_CDK2^3
Model Type:
Genetic
Model Genotype: Homozygous
Mutation: dsRNA for RNAi of Cdk2 (FBgn0004107) under UAS control.
Allele Type: Loss-of-function
Strain of Origin: Not reported
Genetic Background:
ES Cell Line:
Mutant ES Cell Line:
Model Source:
Model Genotype: Homozygous
Mutation: dsRNA for RNAi of Cdk2 (FBgn0004107) under UAS control.
Allele Type: Loss-of-function
Strain of Origin: Not reported
Genetic Background:
ES Cell Line:
Mutant ES Cell Line:
Model Source:
F_CDK2_2_KD_RNAI
Model Type:
Genetic
Model Genotype: Homozygous
Mutation: RNAi-based knockdown of Cdk2 gene.
Allele Type: Loss-of-function
Strain of Origin: Not reported
Genetic Background:
ES Cell Line:
Mutant ES Cell Line:
Model Source:
Model Genotype: Homozygous
Mutation: RNAi-based knockdown of Cdk2 gene.
Allele Type: Loss-of-function
Strain of Origin: Not reported
Genetic Background:
ES Cell Line:
Mutant ES Cell Line:
Model Source:
F_CDK2_1_KD_CDK2^3
Category
Entity
Quantity
Experimental Paradigm
Age at Testing
Synaptic morphology1
Abnormal
Description: Cdk2 mutant larvae showed aberrant innervation patterns of type III axons in muscle 13 (M13) neuromuscular junctions compared to controls.
Confocal microscopy
larval stage
Gene expression1
Decreased
Description: Cdk2 mutants show significant downregulation of rl transcript expression compared to wildtype controls.
Quantitative pcr (qrt-pcr)
Unreported
Not Reported:
Circadian sleep/wake cycle, Communications, Developmental profile, Emotion, Immune response, Learning & memory, Maternal behavior, Motor phenotype, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, Sensory, Social behavior
F_CDK2_2_KD_RNAI
Category
Entity
Quantity
Experimental Paradigm
Age at Testing
Synaptic morphology1
Abnormal
Description: Cdk2 RNAi mutant larvae showed aberrant innervation patterns of type III axons in muscle 13 (M13) compared to controls.
Confocal microscopy
larval stage
Not Reported:
Circadian sleep/wake cycle, Communications, Developmental profile, Emotion, Immune response, Learning & memory, Maternal behavior, Molecular profile, Motor phenotype, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, Sensory, Social behavior
