CDH10
Homo sapiens
Gene Name: cadherin 10, type 2 (T2-cadherin)
Aliases: T2-cadherin
Chromosome No: 5
Chromosome Band: 5p14.2-p14.1
Genetic Category: Genetic Association-Rare single gene variant
Aliases: T2-cadherin
Chromosome No: 5
Chromosome Band: 5p14.2-p14.1
Genetic Category: Genetic Association-Rare single gene variant
Summary Statistics:
ASD Reports: 11
Recent Reports: 2
Annotated variants: 20
Associated CNVs: 7
Evidence score: 3
ASD Reports: 11
Recent Reports: 2
Annotated variants: 20
Associated CNVs: 7
Evidence score: 3
| Associated Disorders: |
|
Relevance to Autism
Genetic association has been found between the CDH10 gene and autism in two large cohorts (AGRE and ACC) of European ancestry and replicated in two other cohorts (CAP and CART) (Wang et al., 2009).
Molecular Function
cell adhesion
External Links
References
Type
Title
Type of Disorder
Associated Disorders
Author, Year
Primary
Common genetic variants on 5p14.1 associate with autism spectrum disorders.
ASD
Positive Association
A genome-wide association study of autism incorporating autism diagnostic interview-revised, autism diagnostic observation schedule, and social res...
ASD
Positive Association
The association of rs4307059 and rs35678 markers with autism spectrum disorders is replicated in Italian families.
ASD
Support
Inherited and De Novo Genetic Risk for Autism Impacts Shared Networks.
ASD
Support
De novo genic mutations among a Chinese autism spectrum disorder cohort.
ASD
Highly Cited
The human cadherin-10 gene: complete coding sequence, predominant expression in the brain, and mapping on chromosome 5p13-14.
Highly Cited
Identification of three human type-II classic cadherins and frequent heterophilic interactions between different subclasses of type-II classic cadh...
Recent Recommendation
The intercellular adhesion molecule, cadherin-10, is a marker for human prostate luminal epithelial cells that is not expressed in prostate cancer.
Recent Recommendation
Cadherin-10 is a novel blood-brain barrier adhesion molecule in human and mouse.
Rare
Variant ID
Variant Type
Allele Change
Residue Change
Inheritance Pattern
Inheritance Association
Family Type
Author, Year
Common
Variant ID
Polymorphism
SNP ID
Allele Change
Residue Change
Population Origin
Population Stage
Author, Year
GEN042C007
intergenic_variant
rs4307059
C/T
Italian Autism Network (ITAN)
Discovery
GEN042C008
intergenic_variant
rs10038113
Discovery cohort: 2165 participants from AGRE
Discovery
GEN042C009
intergenic_variant
rs12518194
Discovery cohort: 2165 participants from AGRE
Discovery
GEN042C010
intergenic_variant
rs1896731
Discovery cohort: 2165 participants from AGRE
Discovery
GEN042C011
intergenic_variant
rs4307059
C/T
Discovery cohort: 2165 participants from AGRE
Discovery
GEN042C012
intergenic_variant
rs4327572
Discovery cohort: 2165 participants from AGRE
Discovery
GEN042C013
intergenic_variant
rs7704909
Discovery cohort: 2165 participants from AGRE
Discovery
