Aliases: IGSF4D, NECL3, Necl-3, SynCAM 2, synCAM2
Chromosome No: 3
Chromosome Band: 3p12.1
Genetic Category: Genetic association-Rare single gene variant
ASD Reports: 4
Recent Reports: 0
Annotated variants: 2
Associated CNVs: 6
Evidence score: null
Relevance to Autism
CADM2 was identified in an ASD candidate gene via homozygous haplotype mapping analysis performed on 1,402 Autism Genome Project trios genotyped for 1 million single nucleotide polymorphisms (SNPs) (Casey et al., 2012).
Adhesion molecule that engages in homo- and heterophilic interactions with the other nectin-like family members, leading to cell aggregation. Important for synapse organization, providing regulated trans-synaptic adhesion.