ALOX5AP
Homo sapiens
Gene Name: arachidonate 5-lipoxygenase-activating protein
Aliases: FLAP
Chromosome No: 3
Chromosome Band: 13q12.3
Genetic Category: Functional
Aliases: FLAP
Chromosome No: 3
Chromosome Band: 13q12.3
Genetic Category: Functional
Summary Statistics:
ASD Reports: 4
Recent Reports: 1
Annotated variants: 0
Associated CNVs: 12
Evidence score: null
ASD Reports: 4
Recent Reports: 1
Annotated variants: 0
Associated CNVs: 12
Evidence score: null
| Associated Disorders: |
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Relevance to Autism
Differential expression of the ALOX5AP gene has been shown to occur in some autistic individuals (Hu et al., 2006).
Molecular Function
The encoded protein mediates leukotriene synthesis.
External Links
References
Type
Title
Type of Disorder
Associated Disorders
Author, Year
Primary
Gene expression profiling of lymphoblastoid cell lines from monozygotic twins discordant in severity of autism reveals differential regulation of n...
ASD
Highly Cited
Arachidonate 5-lipoxygenase and its activating protein: prominent hippocampal expression and role in somatostatin signaling.
Highly Cited
Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis.
Recent Recommendation
Expression of 5-lipoxygenase and leukotriene A4 hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability.