|
|
Summary Statistics:
ASD Reports: 10
Recent Reports: 6
Annotated variants: 4
Associated CNVs: 3
Evidence score: null
Gene Score: 4
Relevance to Autism
Studies have found genetic association between the ADRB2 gene and autism. Association was found in the AGRE cohort along with additional samples.
Molecular Function
This gene encodes beta-2-adrenergic receptor which is a member of the G protein- coupled receptor superfamily.
References
Primary
beta2-Adrenergic receptor gene variants and risk for autism in the AGRE cohort.
ASD
Positive Association
beta2-adrenergic receptor activation and genetic polymorphisms in autism: data from dizygotic twins.
ASD
Highly Cited
Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A.
Highly Cited
Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor.
Recent Recommendation
Activation of serum response element by D2 dopamine receptor is governed by Gbetagamma-mediated MAPK and Rho pathways and regulated by RGS proteins.
Recent Recommendation
beta(2)-Adrenoceptor-mediated facilitation of glutamatergic transmission in rat ventromedial hypothalamic neurons.
Recent Recommendation
Quantitative mRNA analysis of serotonin 5-HT and adrenergic receptors in the mouse embryonic telencephalon.
Recent Recommendation
Cell shape and negative links in regulatory motifs together control spatial information flow in signaling networks.
Recent Recommendation
High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor.
Recent Recommendation
Crystal structure of the human beta2 adrenergic G-protein-coupled receptor.
No Rare Variants Available
GEN004C001
missense_variant
rs1042713
c.46A>G
p.Arg16Gly
AGRE plus additional
Discovery
GEN004C002
missense_variant
rs1042714
c.79C>G
p.Gln27Glu
AGRE plus additional
Discovery
GEN004C003
missense_variant
rs1042713
c.46A>G
p.Arg16Gly
AGRE
Replication
GEN004C004
missense_variant
rs1042714
c.79C>G
p.Gln27Glu
AGRE
Replication
No Animal Model Data Available
Summary Statistics:
Total Interactions: 194
Total Publications: 27
| Interactor Symbol |
Interactor Name |
Interactor Organism |
Entrez ID |
Uniprot ID |
Interaction Type |
Evidence |
Reference |
| 2-Mar |
E3 ubiquitin-protein ligase MARCH2 |
|
51257
|
Q9P0N8
|
|
LC-MS/MS
|
Han SO , et al. 2012
|
| ACTG1 |
actin, gamma 1 |
|
71
|
P63261
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| ADRB2 |
adrenergic, beta-2-, receptor, surface |
|
154
|
P07550
|
|
IP/WB; Bioluminescence resonance energy transfer assay
|
McVey M , et al. 2001
|
| ADRBK1 |
adrenergic, beta, receptor kinase 1 |
|
156
|
P25098
|
|
GST
|
Fan G , et al. 2001
|
| AIFM1 |
apoptosis-inducing factor, mitochondrion-associated, 1 |
|
9131
|
O95831
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| AKAP12 |
A kinase (PRKA) anchor protein 12 |
|
9590
|
Q02952
|
|
GST; IP/WB
|
Fan G , et al. 2001
|
| ALDH18A1 |
aldehyde dehydrogenase 18 family, member A1 |
|
5832
|
P54886
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| AMFR |
autocrine motility factor receptor, E3 ubiquitin protein ligase |
|
267
|
Q9UKV5
|
|
TAP; MS; IP
|
Roy SJ , et al. 2013
|
| ARRB2 |
arrestin, beta 2 |
|
409
|
P32121
|
|
IP/WB; Bioluminescence resonance energy transfer assay
|
Tian X , et al. 2016
|
| Arrb2 |
Beta-arrestin-2 |
|
25388
|
P29067
|
|
IP/WB
|
Shenoy SK , et al. 2007
|
| ARRDC3 |
arrestin domain containing 3 |
|
57561
|
Q96B67
|
|
IP/WB
|
Nabhan JF , et al. 2010
|
| ARRDC3 |
arrestin domain containing 3 |
|
57561
|
Q96B67
|
|
IP/WB; Bioluminescence resonance energy transfer assay; in vitro binding assay; Co-localization
|
Tian X , et al. 2016
|
| ATP1A1 |
ATPase, Na+/K+ transporting, alpha 1 polypeptide |
|
476
|
P05023
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| ATP1B3 |
ATPase, Na+/K+ transporting, beta 3 polypeptide |
|
483
|
P54709
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| ATP2A2 |
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 |
|
488
|
P16615
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| ATP2B4 |
ATPase, Ca++ transporting, plasma membrane 4 |
|
493
|
P23634
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| ATP5A1 |
ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle |
|
498
|
P25705
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| ATP5B |
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide |
|
506
|
P06576
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| ATP5C1 |
ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 |
|
509
|
P36542
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| ATP5O |
ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit |
|
539
|
P48047
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| C19orf6 |
transmembrane protein 259 |
|
91304
|
B3KTL0
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| C1QBP |
complement component 1, q subcomponent binding protein |
|
708
|
Q07021
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| CACNA1C |
calcium channel, voltage-dependent, L type, alpha 1C subunit |
|
775
|
Q13936
|
|
IP/WB
|
Davare MA , et al. 2001
|
| CACNA1C |
calcium voltage-gated channel subunit alpha1 C |
|
100101555
|
P15381
|
|
in vitro binding assay; IP/WB; Co-localization
|
Patriarchi T , et al. 2016
|
| CALM1 |
calmodulin 1 (phosphorylase kinase, delta) |
|
801
|
P62158
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| CALM2 |
calmodulin 2 (phosphorylase kinase, delta) |
|
805
|
P62158
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| CALM3 |
calmodulin 3 (phosphorylase kinase, delta) |
|
808
|
B4DJ51
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| CANX |
calnexin |
|
821
|
P27824
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| CAPNS1 |
calpain, small subunit 1 |
|
826
|
P04632
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| CAV3 |
caveolin 3 |
|
29161
|
P51638
|
|
IP/WB
|
Fuhs SR and Insel PA 2011
|
| CLGN |
Calmegin |
|
1047
|
O14967
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| CNNM3 |
cyclin M3 |
|
26505
|
Q8NE01
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| CUL2 |
cullin 2 |
|
8453
|
Q13617
|
|
GST; IP/WB; LC-MS/MS; Far Western Blot
|
Xie L , et al. 2009
|
| DAD1 |
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 |
|
1603
|
P61803
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| DLAT |
dihydrolipoamide S-acetyltransferase |
|
1737
|
P10515
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| DNAJB11 |
DnaJ (Hsp40) homolog, subfamily B, member 11 |
|
51726
|
Q9UBS4
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| DSG2 |
desmoglein 2 |
|
1829
|
Q14126
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| EEF1A1 |
eukaryotic translation elongation factor 1 alpha 1 |
|
1915
|
P68104
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| EEF1B2 |
eukaryotic translation elongation factor 1 beta 2 |
|
1933
|
P24534
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| EEF1D |
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) |
|
1936
|
B2RAR6
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| EEF1G |
eukaryotic translation elongation factor 1 gamma |
|
1937
|
P26641
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| EEF2 |
eukaryotic translation elongation factor 2 |
|
1938
|
P13639
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| EGLN3 |
egl nine homolog 3 (C. elegans) |
|
112399
|
Q9H6Z9
|
|
GST; IP/WB; LC-MS/MS; Far Western Blot
|
Xie L , et al. 2009
|
| EIF2B1 |
Translation initiation factor eIF-2B subunit alpha |
|
1967
|
Q14232
|
|
Y2H; IP/WB
|
Klein U , et al. 1997
|
| EIF4A1 |
eukaryotic translation initiation factor 4A1 |
|
1973
|
P60842
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| ERLIN2 |
ER lipid raft associated 2 |
|
11160
|
O94905
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| ETFB |
Electron transfer flavoprotein subunit beta |
|
2109
|
P38117
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| FAM162A |
Protein FAM162A |
|
26355
|
Q96A26
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| FKBP8 |
FK506 binding protein 8, 38kDa |
|
23770
|
Q14318
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| FLNA |
filamin A, alpha |
|
2316
|
P21333
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| GAPDH |
glyceraldehyde-3-phosphate dehydrogenase |
|
2597
|
P04406
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| GCDH |
glutaryl-CoA dehydrogenase |
|
2639
|
Q92947
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| GFM1 |
G elongation factor, mitochondrial 1 |
|
85476
|
E5KND5
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| GNAI2 |
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 |
|
2771
|
B3KP24
|
|
Bioluminescence resonance energy transfer assay
|
Gals C , et al. 2005
|
| GNAI3 |
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 |
|
2773
|
P08754
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| GNAS |
Neuroendocrine secretory protein 55 |
|
2778
|
O95467
|
|
Bioluminescence resonance energy transfer assay
|
Gals C , et al. 2005
|
| GNB1 |
guanine nucleotide binding protein (G protein), beta polypeptide 1 |
|
2782
|
P62873
|
|
Bioluminescence resonance energy transfer assay
|
Gals C , et al. 2005
|
| GNB2 |
guanine nucleotide binding protein (G protein), beta polypeptide 2 |
|
2783
|
P62879
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| GNB2L1 |
guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 |
|
10399
|
P63244
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| GNB4 |
guanine nucleotide binding protein (G protein), beta polypeptide 4 |
|
59345
|
Q9HAV0
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| GNG12 |
guanine nucleotide binding protein (G protein), gamma 12 |
|
55970
|
Q69YP5
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| GNG2 |
guanine nucleotide binding protein (G protein), gamma 2 |
|
54331
|
P59768
|
|
Bioluminescence resonance energy transfer assay
|
Gals C , et al. 2005
|
| Gria1 |
glutamate receptor, ionotropic, AMPA1 (alpha 1) |
|
14799
|
P23818
|
|
IP/WB
|
Patriarchi T , et al. 2016
|
| GRK6 |
G protein-coupled receptor kinase 6 |
|
2870
|
P43250
|
|
IP/WB
|
Stoffel RH , et al. 1998
|
| HADHB |
hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit |
|
3032
|
P55084
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| HLA-B |
major histocompatibility complex, class I, B |
|
3106
|
P01889
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| HLA-C |
major histocompatibility complex, class I, C |
|
3107
|
O19617
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| HNRNPA2B1 |
heterogeneous nuclear ribonucleoprotein A2/B1 |
|
3181
|
P22626
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| HNRNPF |
eterogeneous nuclear ribonucleoprotein F |
|
3185
|
P52597
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| HNRNPH1 |
heterogeneous nuclear ribonucleoprotein H1 (H) |
|
3187
|
P31943
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| HNRNPK |
heterogeneous nuclear ribonucleoprotein K |
|
3190
|
P61978
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| HNRNPU |
heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) |
|
3192
|
Q00839
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| HSD17B12 |
hydroxysteroid (17-beta) dehydrogenase 12 |
|
51144
|
Q53GQ0
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| HSD17B4 |
hydroxysteroid (17-beta) dehydrogenase 4 |
|
3295
|
B2R659
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| HSDL2 |
hydroxysteroid dehydrogenase like 2 |
|
84263
|
Q6YN16
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| HSP90B1 |
heat shock protein 90kDa beta (Grp94), member 1 |
|
7184
|
P14625
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| HSPA1A |
heat shock 70kDa protein 1A |
|
3303
|
P08107
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| HSPA1B |
heat shock 70kDa protein 1B |
|
3304
|
A8K5I0
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| HSPA5 |
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) |
|
3309
|
Q2KHP4
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| HSPA9 |
heat shock 70kDa protein 9 (mortalin) |
|
3313
|
P38646
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| HSPD1 |
heat shock 60kDa protein 1 (chaperonin) |
|
3329
|
P10809
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| IDH2 |
isocitrate dehydrogenase 2 (NADP+), mitochondrial |
|
3418
|
P48735
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| IDH3A |
isocitrate dehydrogenase 3 (NAD+) alpha |
|
3419
|
P50213
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| IDH3B |
isocitrate dehydrogenase 3 (NAD+) beta |
|
3420
|
O43837
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| IDH3G |
isocitrate dehydrogenase 3 (NAD+) gamma |
|
3421
|
P51553
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| ILVBL |
ilvB (bacterial acetolactate synthase)-like |
|
10994
|
A1L0T0
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| IMMT |
inner membrane protein, mitochondrial |
|
10989
|
Q16891
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| ITCH |
itchy E3 ubiquitin protein ligase |
|
83737
|
Q96J02
|
|
IP/WB
|
Shea FF , et al. 2012
|
| JKAMP |
JNK1/MAPK8-associated membrane protein |
|
51528
|
Q9P055
|
|
TAP; MS; IP/WB
|
Roy SJ , et al. 2013
|
| KCNJ3 |
potassium inwardly-rectifying channel, subfamily J, member 3 |
|
3760
|
B4DEW7
|
|
GST; IP/WB; Bioluminescence resonance energy transfer assay
|
Lavine N , et al. 2002
|
| KCNJ5 |
potassium inwardly-rectifying channel, subfamily J, member 5 |
|
3762
|
P48544
|
|
GST; IP/WB; Bioluminescence resonance energy transfer assay
|
Lavine N , et al. 2002
|
| KIAA0368 |
KIAA0368 |
|
23392
|
J3KN16
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| KPNB1 |
karyopherin (importin) beta 1 |
|
3837
|
Q14974
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| KRT1 |
keratin 1 |
|
3848
|
P04264
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| KRT10 |
keratin 10 |
|
3858
|
P13645
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| KRT2 |
keratin 2 |
|
3849
|
P35908
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| KRT5 |
keratin 5 |
|
3852
|
P13647
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| KRT9 |
keratin 9 |
|
3857
|
P35527
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| LMNB1 |
lamin B1 |
|
4001
|
P20700
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| LONP1 |
lon peptidase 1, mitochondrial |
|
9361
|
P36776
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| LRPPRC |
leucine-rich pentatricopeptide repeat containing |
|
10128
|
E5KNY5
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| MAPK14 |
mitogen-activated protein kinase 14 |
|
1432
|
Q16539
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| MCCC2 |
methylcrotonoyl-CoA carboxylase 2 (beta) |
|
64087
|
Q9HCC0
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| MDM2 |
Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) |
|
4193
|
Q00987
|
|
Y2H; IP/WB
|
Shenoy SK , et al. 2001
|
| MRPL12 |
mitochondrial ribosomal protein L12 |
|
6182
|
P52815
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| MTHFD1 |
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase |
|
4522
|
G3V2B8
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| MTHFD1L |
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like |
|
25902
|
B7ZM99
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| MYLK2 |
myosin light chain kinase 2 |
|
85366
|
Q9H1R3
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| NDUFA4 |
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa |
|
4697
|
O00483
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| NDUFA5 |
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa |
|
4698
|
Q16718
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| NDUFS2 |
NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) |
|
4720
|
O75306
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| NDUFS3 |
NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) |
|
4722
|
O75489
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| NDUFV1 |
NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa |
|
4723
|
P49821
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| NEDD4 |
neural precursor cell expressed, developmentally down-regulated 4 |
|
4734
|
P46934
|
|
IP/WB
|
Nabhan JF , et al. 2010
|
| NPLOC4 |
nuclear protein localization 4 homolog (S. cerevisiae) |
|
55666
|
Q8TAT6
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| NSF |
N-ethylmaleimide-sensitive factor |
|
4905
|
P46459
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| NUP155 |
nucleoporin 155kDa |
|
9631
|
O75694
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| NUP210 |
nucleoporin 210kDa |
|
23225
|
Q8TEM1
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| NUP93 |
nucleoporin 93kDa |
|
9688
|
Q8N1F7
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| OAT |
ornithine aminotransferase |
|
4942
|
P04181
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| OPRD1 |
Delta-type opioid receptor |
|
4985
|
P41143
|
|
IP/WB; Bioluminescence resonance energy transfer assay
|
McVey M , et al. 2001
|
| OXTR |
oxytocin receptor |
|
5021
|
P30559
|
|
IP/WB; Bioluminescence resonance energy transfer assay; Protein-fragment complementation assay
|
Wrzal PK , et al. 2011
|
| PC |
pyruvate carboxylase |
|
5091
|
P11498
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| PCBP1 |
poly(rC) binding protein 1 |
|
5093
|
Q15365
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| PCBP2 |
poly(rC) binding protein 2 |
|
5094
|
Q15366
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| PDHA1 |
pyruvate dehydrogenase (lipoamide) alpha 1 |
|
5160
|
P08559
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| PDHB |
pyruvate dehydrogenase (lipoamide) beta |
|
5162
|
P11177
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| PDIA6 |
protein disulfide isomerase family A, member 6 |
|
10130
|
Q15084
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| PGRMC1 |
progesterone receptor membrane component 1 |
|
10857
|
O00264
|
|
TAP; MS; IP/WB
|
Roy SJ , et al. 2013
|
| PHB |
prohibitin |
|
5245
|
P35232
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| PHB2 |
prohibitin 2 |
|
11331
|
Q99623
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| PON2 |
paraoxonase 2 |
|
5445
|
Q15165
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| PPP3CA |
protein phosphatase 3, catalytic subunit, alpha isozyme |
|
5530
|
Q08209
|
|
IP/WB
|
Shih M , et al. 1999
|
| PRKDC |
protein kinase, DNA-activated, catalytic polypeptide |
|
5591
|
P78527
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| PSMD2 |
proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 |
|
5708
|
Q13200
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| PTGER1 |
Prostaglandin E2 receptor EP1 subtype |
|
5731
|
P34995
|
|
IP/WB; Bioluminescence resonance energy transfer assay
|
McGraw DW , et al. 2006
|
| RAB18 |
RAB18, member RAS oncogene family |
|
22931
|
Q9NP72
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| RAN |
RAN, member RAS oncogene family |
|
5901
|
A8K3Z8
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| RANBP2 |
RAN binding protein 2 |
|
5903
|
P49792
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| REL |
v-rel reticuloendotheliosis viral oncogene homolog (avian) |
|
5966
|
Q04864
|
|
Y2H
|
Corominas R , et al. 2014
|
| RNF5 |
ring finger protein 5, E3 ubiquitin protein ligase |
|
6048
|
Q99942
|
|
TAP; MS; IP/WB
|
Roy SJ , et al. 2013
|
| RPLP1 |
ribosomal protein, large, P1 |
|
6176
|
P05386
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| RPN1 |
ribophorin I |
|
6184
|
P04843
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| RPN2 |
ribophorin II |
|
6185
|
P04844
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| RPS5 |
ribosomal protein S5 |
|
6193
|
P46782
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| SEC22B |
Vesicle-trafficking protein SEC22b |
|
9554
|
O75396
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| SEC61A1 |
Sec61 alpha 1 subunit (S. cerevisiae) |
|
29927
|
P61619
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| SERPINH1 |
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) |
|
871
|
A8K259
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| SHMT2 |
serine hydroxymethyltransferase 2 (mitochondrial) |
|
6472
|
P34897
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| SLC1A5 |
solute carrier family 1 (neutral amino acid transporter), member 5 |
|
6510
|
B4DWS4
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| SLC25A10 |
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10 |
|
1468
|
Q9UBX3
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| SLC25A11 |
solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 |
|
8402
|
Q6IBH0
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| SLC25A13 |
solute carrier family 25 (aspartate/glutamate carrier), member 13 |
|
10165
|
Q9UJS0
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| SLC25A3 |
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 |
|
5250
|
Q00325
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| SLC25A5 |
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 |
|
292
|
P05141
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| SLC25A6 |
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 |
|
293
|
P12236
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| SLC39A14 |
solute carrier family 39 (zinc transporter), member 14 |
|
23516
|
Q15043
|
|
X-ray crystallography
|
Karthikeyan S , et al. 2002
|
| SLC9A3R1 |
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 |
|
9368
|
O14745
|
|
GST; Blot overlay assay
|
Hall RA , et al. 1998
|
| SLC9A3R2 |
solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 |
|
9351
|
Q6NTG0
|
|
GST; Blot overlay assay; TAP; MS
|
Hall RA , et al. 1998
|
| SLIRP |
SRA stem-loop interacting RNA binding protein |
|
81892
|
Q9GZT3
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| SPTLC1 |
serine palmitoyltransferase, long chain base subunit 1 |
|
10558
|
O15269
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| SRPRB |
signal recognition particle receptor, B subunit |
|
58477
|
Q549N5
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| SSR4 |
signal sequence receptor, delta |
|
6748
|
P51571
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| STOM |
stomatin |
|
2040
|
P27105
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| SV2A |
Synaptic vesicle glycoprotein 2A |
|
9900
|
Q7L0J3
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| SYNJ2BP |
synaptojanin 2 binding protein |
|
55333
|
P57105
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| TARDBP |
TAR DNA binding protein |
|
23435
|
Q13148
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| TAS2R14 |
taste 2 receptor member 14 |
|
50840
|
Q9NYV8
|
|
IP/WB; Co-localization
|
Kim D , et al. 2016
|
| TFRC |
transferrin receptor (p90, CD71) |
|
7037
|
P02786
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| TIMM50 |
translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) |
|
92609
|
Q3ZCQ8
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| TM9SF3 |
transmembrane 9 superfamily member 3 |
|
56889
|
Q9HD45
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| TMEM33 |
transmembrane protein 33 |
|
55161
|
P57088
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| TMUB1 |
transmembrane and ubiquitin-like domain containing 1 |
|
83590
|
Q9BVT8
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| TMX1 |
thioredoxin-related transmembrane protein 1 |
|
81542
|
Q9H3N1
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| TOMM70A |
translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae) |
|
9868
|
O94826
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| TRAF1 |
TNF receptor-associated factor 1 |
|
7185
|
Q13077
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| TTN |
titin |
|
7273
|
Q8WZ42
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| TUBB |
tubulin, beta |
|
203068
|
P07437
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| TUBB2A |
tubulin, beta 2A class IIa |
|
7280
|
Q13885
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| TUFM |
Tu translation elongation factor, mitochondrial |
|
7284
|
P49411
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| UBA52 |
ubiquitin A-52 residue ribosomal protein fusion product 1 |
|
7311
|
P62987
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| UBB |
ubiquitin B |
|
7314
|
P0CG47
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| UBC |
ubiquitin C |
|
7316
|
P63279
|
|
IP/WB
|
Shenoy SK , et al. 2001
|
| UBXN8 |
UBX domain-containing protein 8 |
|
7993
|
O00124
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| UCHL1 |
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) |
|
7345
|
P09936
|
|
GST; Y2H; IP/WB
|
Weber B , et al. 2009
|
| UFD1L |
ubiquitin fusion degradation 1 like (yeast) |
|
7353
|
Q541A5
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| UQCRC2 |
Cytochrome b-c1 complex subunit 2, mitochondrial |
|
7385
|
P22695
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| USP20 |
ubiquitin specific peptidase 20 |
|
10868
|
Q9Y2K6
|
|
LC-MS/MS
|
Han SO , et al. 2012
|
| USP33 |
ubiquitin specific peptidase 33 |
|
23032
|
Q8TEY7
|
|
LC-MS/MS
|
Han SO , et al. 2012
|
| VCP |
valosin containing protein |
|
7415
|
P55072
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| VDAC2 |
voltage-dependent anion channel 2 |
|
7417
|
P45880
|
|
TAP; MS
|
Roy SJ , et al. 2013
|
| VHL |
von Hippel-Lindau tumor suppressor |
|
7428
|
P40337
|
|
GST; IP/WB; LC-MS/MS; Far Western Blot
|
Xie L , et al. 2009
|
| SRC |
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) |
|
6714
|
P12931
|
|
IP/WB
|
Cao W , et al. 2000
|
| GRB2 |
growth factor receptor-bound protein 2 |
|
2885
|
P62993
|
|
GST; IP/WB
|
Karoor V , et al. 1998
|
|
