Xq22.1-q23CNV Type: Deletion-Duplication
Largest CNV size: 11000000 bp
Statistics Box:
Number of Reports: 2
Number of Reports: 2
Summary Information
CNVs within this region were found to be signficantly enriched in cases with developmental delay, intellectual disability, and other neurodevelopmental disorders (including ASD), compared to controls (Girirajan et al., 2012).
Additional Locus Information
References
Major Reports
Title
Author, Year
Report Class
CNV Type
Phenotypic heterogeneity of genomic disorders and rare copy-number variants.
Deletion-Duplication
Minor Reports
Cases
Cohort ID
Author, Year
Descripton
Cohort Size
Diagnosis
Age
Gender
CNV Size
Deletion
Duplication
Total CNV's
akkus_24_ASD/DD/ID_discovery_cases
Patients with developmental delay/intellectual disability, autism spectrum disorder, and/or multiple congenital anomalies consulted by the Department of Medical Genetics at the Health Sciences University Kocaeli Derince Training and Research Hospital between January 1, 2017 and March 30, 2021.
1227
Patients presented with developmental delay/intellectual disability, autism spectrum disorder, and/or multiple congenital anomalies.
57.13% Male
9210864
0
1
1
girirajan_12_ASD/DD/ID_discovery_cases
Samples from affected children submitted to Signature Genomic Laboratories from 2008-2010.
32587
Developmental delay with or without congenital malformations
11000000
3
6
9
Controls
Cohort ID
Author, Year
Descripton
Cohort Size
Diagnosis
Age
Gender
CNV Size
Deletion
Duplication
Total CNV's
girirajan_12_ASD/DD/ID_discovery_controls
Persons found to have no overt neurological disorders during screening for other studies
8329
Control
11000000
0
0
0
Cases
Cohort ID
Geographical Ancestry
Discovery Method
Platform
Algorithm
Software
Validation Method
akkus_24_ASD/DD/ID_discovery_cases
Turkey
Array SNP
Affymetrix CytoScan Optima
ThermoFisher ChAS v.3.1.
girirajan_12_ASD/DD/ID_discovery_cases
aCGH
BACs aCGH, SignatureChipOS
FISH, aCGH, or confirmation by inheritance
Controls
Cohort ID
Geographical Ancestry
Discovery Method
Platform
Algorithm
Software
Validation Method
girirajan_12_ASD/DD/ID_discovery_controls
aCGH
BACs ACGH (SignatureChipoWG) or oligoarray (SignatureChipOS)
Cases
Patient ID
Author, Year
Age
Gender
Primary Diagnosis
Clinical Profile
Cognitive Profile
CNV Start
CNV End
CNV Size
Genome Build
Type Method
Validation
akkus_24_ASD/DD/ID_discovery_cases-case18A
8 yrs.
F
Developmental delay/intellectual disability
Developmental delay/intellectual disability
Developmental delay/intellectual disability
100958242
110169105
9210864
GRCh38
Duplication
No
girirajan_12_ASD/DD/ID_discovery_cases-case2226
NA
NA
Developmental delay
NA
NA
103158416
114170527
11012112
GRCh38
Deletion
NA
girirajan_12_ASD/DD/ID_discovery_cases-case2227
NA
NA
Developmental delay
NA
NA
103158416
114170527
11012112
GRCh38
Deletion
NA
girirajan_12_ASD/DD/ID_discovery_cases-case2228
NA
NA
Developmental delay
NA
NA
103158416
114170527
11012112
GRCh38
Deletion
NA
girirajan_12_ASD/DD/ID_discovery_cases-case2229
NA
NA
Developmental delay
NA
NA
103158416
114170527
11012112
GRCh38
Duplication
NA
girirajan_12_ASD/DD/ID_discovery_cases-case2230
NA
NA
Developmental delay
NA
NA
103158416
114170527
11012112
GRCh38
Duplication
NA
girirajan_12_ASD/DD/ID_discovery_cases-case2231
NA
NA
Developmental delay
NA
NA
103158416
114170527
11012112
GRCh38
Duplication
NA
girirajan_12_ASD/DD/ID_discovery_cases-case2232
NA
NA
Developmental delay
NA
NA
103158416
114170527
11012112
GRCh38
Duplication
NA
girirajan_12_ASD/DD/ID_discovery_cases-case2233
NA
NA
Developmental delay
NA
NA
103158416
114170527
11012112
GRCh38
Duplication
NA
girirajan_12_ASD/DD/ID_discovery_cases-case2234
NA
NA
Developmental delay
NA
NA
103158416
114170527
11012112
GRCh38
Duplication
NA
Controls
No Control Data Available
Cases
Patient ID
Validation Description
Primary Disorder Inheritence
Inheritence
Family Profile
Disease Segregation
Gene Content
Altered Gene Expression
akkus_24_ASD/DD/ID_discovery_cases-case18A
Unknown
BTK,ACSL4,TIMM8A,COL4A6,TSC22D3,DRP2,COL4A5,IL1RAPL2,BEX3,RAB9B,ARMCX1,TCEAL9,ARMCX3,RBM41,TBC1D8B,RADX,NUP62CL,TAF7L,ARMCX6,NXF5,BEX1,NXF3,TEX13B,MTND2P2,TCEAL7,TEX13A,NXF4,NXF2,BEX4,NXT2,TMEM35A,TCEAL4,ARMCX5,RNF128,MORC4,FRMPD3,BHLHB9,ESX1,TMEM164,TRMT2B,BEX2,RIPPLY1,TCEAL3,TCEAL8,ZMAT1,GPRASP2,ATG4A,TCEAL2,PWWP3B,DNAAF6,RAB40A,FAM199X,TCEAL6,H2BW1,TMEM31,PRKCIP1,NRK,CENPI,HNRNPH2,GK4P,GUCY2F,GLA,RAB40AL,VSIG1,BEX5,H2BW2,MORF4L2-AS1,TCEAL5,TMSB15B,NLRP3P1,NCBP2L,ARL13A,KRT18P49,YWHAQP8,RPS5P7,SLC25A53,GLRA4,MFN1P1,FOXN3P1,GTF3C6P2,DNAJA1P3,KCTD9P2,SLC25A53P1,ZCCHC18,DPPA3P1,MIR652,ARMCX7P,NXF2B,H2BW3P,ELF2P1,ARMCX3-AS1,CNEP1R1P1,TMSB15B-AS1,MYCLP1,ARMCX4,CTDSPL2P2,RPSAP59,RPL18AP14,RPL21P132,LINC00630,BEND7P1,SERPINA7P1,NUDT19P2,RPL36A-HNRNPH2,MIR548AN,ARMCX5-GPRASP2,MTND1P32,MIR3978,RNA5SP511,MTND4P32,NANOGNBP3,MTND5P26,TCP11X1,TCP11X2,EEF1A1P40,FRMPD3-AS1,NAP1L4P2,TCEAL3-AS1,RNU6-30P,RPL36A,PSMD10,PRPS1,PLP1,SERPINA7,RNU6-309P,RNU6-345P,RNU6-589P,MTND6P13,RNU6-587P,MTND6P32,MTCO1P19,MTATP6P19,TCP11X3P,RNU6-207P,MTCO3P19,MTCO2P19,TRMT2B-AS1,MTCYBP32,RNU6-934P,CSGALNACT2P2,PPIAP90,IRS4,H3P45,H2BP8,H2BP9,GAPDHP77,TMEM230P1,C3orf49P1,MORF4L2,TCEAL1,GPRASP1,CLDN2,ARMCX2,TMSB15A,MID2,KCNE5
girirajan_12_ASD/DD/ID_discovery_cases-case2226
NA
Unknown
Unknown
Unknown
RPSAP59,BEX4,TCEAL8,TCEAL5,BEX2,TCEAL7,TCEAL9,BEX3,TCEAL3-AS1,MORF4L2-AS1,TMEM31,RNA5SP511,TMSB15B-AS1,DPPA3P1,H2BFWT,H2BFM,ZCCHC18,PHBP10,RPL18AP14,TEX13A,KCTD9P2,RNU6-207P,NAP1L4P2,SERPINA7P1,MIR548AN,RIPPLY1,EEF1A1P40,MYCLP1,DNAJA1P3,KRT18P49,NLRP3P1,TEX13B,IRS4,RNU6-309P,KCNE5,RPS5P7,MIR652,MIR3978,SNORD96B,AMMECR1-IT1,GNG5P2,TDGF1P3,FCF1P4,RNU6-496P,HMGB1P12,SERTM2,EIF4BP7,RPL18AP15,RNA5SP512,ALG13-AS1,DPRXP7,RTL4,HMGB3P30,MIR4329,RN7SL266P,RNU6-1015P,QTRT1P1,RNU1-57P,RN7SL93P,RAB40A,TCEAL4,TCEAL3,TCEAL1,GLRA4,PLP1,RAB9B,SLC25A53,FAM199X,ESX1,RNF128,CLDN2,NUP62CL,FRMPD3-AS1,FRMPD3,PRPS1,NCBP2L,VSIG1,PSMD10,NXT2,GLUD1P9,CAPN6,TRPC5OS,LHFPL1,AMOT,MORF4L2,TMSB15B,SERPINA7,TBC1D8B,RBM41,PIH1D3,TSC22D3,MID2,ATG4A,COL4A6,COL4A5,GUCY2F,ACSL4,AMMECR1,RTL9,CHRDL1,DCX,ALG13,TRPC5,XACT,IL1RAPL2,NRK,MORC4,TMEM164,PAK3
girirajan_12_ASD/DD/ID_discovery_cases-case2227
NA
Unknown
Unknown
Unknown
RPSAP59,BEX4,TCEAL8,TCEAL5,BEX2,TCEAL7,TCEAL9,BEX3,TCEAL3-AS1,MORF4L2-AS1,TMEM31,RNA5SP511,TMSB15B-AS1,DPPA3P1,H2BFWT,H2BFM,ZCCHC18,PHBP10,RPL18AP14,TEX13A,KCTD9P2,RNU6-207P,NAP1L4P2,SERPINA7P1,MIR548AN,RIPPLY1,EEF1A1P40,MYCLP1,DNAJA1P3,KRT18P49,NLRP3P1,TEX13B,IRS4,RNU6-309P,KCNE5,RPS5P7,MIR652,MIR3978,SNORD96B,AMMECR1-IT1,GNG5P2,TDGF1P3,FCF1P4,RNU6-496P,HMGB1P12,SERTM2,EIF4BP7,RPL18AP15,RNA5SP512,ALG13-AS1,DPRXP7,RTL4,HMGB3P30,MIR4329,RN7SL266P,RNU6-1015P,QTRT1P1,RNU1-57P,RN7SL93P,RAB40A,TCEAL4,TCEAL3,TCEAL1,GLRA4,PLP1,RAB9B,SLC25A53,FAM199X,ESX1,RNF128,CLDN2,NUP62CL,FRMPD3-AS1,FRMPD3,PRPS1,NCBP2L,VSIG1,PSMD10,NXT2,GLUD1P9,CAPN6,TRPC5OS,LHFPL1,AMOT,MORF4L2,TMSB15B,SERPINA7,TBC1D8B,RBM41,PIH1D3,TSC22D3,MID2,ATG4A,COL4A6,COL4A5,GUCY2F,ACSL4,AMMECR1,RTL9,CHRDL1,DCX,ALG13,TRPC5,XACT,IL1RAPL2,NRK,MORC4,TMEM164,PAK3
girirajan_12_ASD/DD/ID_discovery_cases-case2228
NA
Unknown
Unknown
Unknown
RPSAP59,BEX4,TCEAL8,TCEAL5,BEX2,TCEAL7,TCEAL9,BEX3,TCEAL3-AS1,MORF4L2-AS1,TMEM31,RNA5SP511,TMSB15B-AS1,DPPA3P1,H2BFWT,H2BFM,ZCCHC18,PHBP10,RPL18AP14,TEX13A,KCTD9P2,RNU6-207P,NAP1L4P2,SERPINA7P1,MIR548AN,RIPPLY1,EEF1A1P40,MYCLP1,DNAJA1P3,KRT18P49,NLRP3P1,TEX13B,IRS4,RNU6-309P,KCNE5,RPS5P7,MIR652,MIR3978,SNORD96B,AMMECR1-IT1,GNG5P2,TDGF1P3,FCF1P4,RNU6-496P,HMGB1P12,SERTM2,EIF4BP7,RPL18AP15,RNA5SP512,ALG13-AS1,DPRXP7,RTL4,HMGB3P30,MIR4329,RN7SL266P,RNU6-1015P,QTRT1P1,RNU1-57P,RN7SL93P,RAB40A,TCEAL4,TCEAL3,TCEAL1,GLRA4,PLP1,RAB9B,SLC25A53,FAM199X,ESX1,RNF128,CLDN2,NUP62CL,FRMPD3-AS1,FRMPD3,PRPS1,NCBP2L,VSIG1,PSMD10,NXT2,GLUD1P9,CAPN6,TRPC5OS,LHFPL1,AMOT,MORF4L2,TMSB15B,SERPINA7,TBC1D8B,RBM41,PIH1D3,TSC22D3,MID2,ATG4A,COL4A6,COL4A5,GUCY2F,ACSL4,AMMECR1,RTL9,CHRDL1,DCX,ALG13,TRPC5,XACT,IL1RAPL2,NRK,MORC4,TMEM164,PAK3
girirajan_12_ASD/DD/ID_discovery_cases-case2229
NA
Unknown
Unknown
Unknown
RPSAP59,BEX4,TCEAL8,TCEAL5,BEX2,TCEAL7,TCEAL9,BEX3,TCEAL3-AS1,MORF4L2-AS1,TMEM31,RNA5SP511,TMSB15B-AS1,DPPA3P1,H2BFWT,H2BFM,ZCCHC18,PHBP10,RPL18AP14,TEX13A,KCTD9P2,RNU6-207P,NAP1L4P2,SERPINA7P1,MIR548AN,RIPPLY1,EEF1A1P40,MYCLP1,DNAJA1P3,KRT18P49,NLRP3P1,TEX13B,IRS4,RNU6-309P,KCNE5,RPS5P7,MIR652,MIR3978,SNORD96B,AMMECR1-IT1,GNG5P2,TDGF1P3,FCF1P4,RNU6-496P,HMGB1P12,SERTM2,EIF4BP7,RPL18AP15,RNA5SP512,ALG13-AS1,DPRXP7,RTL4,HMGB3P30,MIR4329,RN7SL266P,RNU6-1015P,QTRT1P1,RNU1-57P,RN7SL93P,RAB40A,TCEAL4,TCEAL3,TCEAL1,GLRA4,PLP1,RAB9B,SLC25A53,FAM199X,ESX1,RNF128,CLDN2,NUP62CL,FRMPD3-AS1,FRMPD3,PRPS1,NCBP2L,VSIG1,PSMD10,NXT2,GLUD1P9,CAPN6,TRPC5OS,LHFPL1,AMOT,MORF4L2,TMSB15B,SERPINA7,TBC1D8B,RBM41,PIH1D3,TSC22D3,MID2,ATG4A,COL4A6,COL4A5,GUCY2F,ACSL4,AMMECR1,RTL9,CHRDL1,DCX,ALG13,TRPC5,XACT,IL1RAPL2,NRK,MORC4,TMEM164,PAK3
girirajan_12_ASD/DD/ID_discovery_cases-case2230
NA
Unknown
Unknown
Unknown
RPSAP59,BEX4,TCEAL8,TCEAL5,BEX2,TCEAL7,TCEAL9,BEX3,TCEAL3-AS1,MORF4L2-AS1,TMEM31,RNA5SP511,TMSB15B-AS1,DPPA3P1,H2BFWT,H2BFM,ZCCHC18,PHBP10,RPL18AP14,TEX13A,KCTD9P2,RNU6-207P,NAP1L4P2,SERPINA7P1,MIR548AN,RIPPLY1,EEF1A1P40,MYCLP1,DNAJA1P3,KRT18P49,NLRP3P1,TEX13B,IRS4,RNU6-309P,KCNE5,RPS5P7,MIR652,MIR3978,SNORD96B,AMMECR1-IT1,GNG5P2,TDGF1P3,FCF1P4,RNU6-496P,HMGB1P12,SERTM2,EIF4BP7,RPL18AP15,RNA5SP512,ALG13-AS1,DPRXP7,RTL4,HMGB3P30,MIR4329,RN7SL266P,RNU6-1015P,QTRT1P1,RNU1-57P,RN7SL93P,RAB40A,TCEAL4,TCEAL3,TCEAL1,GLRA4,PLP1,RAB9B,SLC25A53,FAM199X,ESX1,RNF128,CLDN2,NUP62CL,FRMPD3-AS1,FRMPD3,PRPS1,NCBP2L,VSIG1,PSMD10,NXT2,GLUD1P9,CAPN6,TRPC5OS,LHFPL1,AMOT,MORF4L2,TMSB15B,SERPINA7,TBC1D8B,RBM41,PIH1D3,TSC22D3,MID2,ATG4A,COL4A6,COL4A5,GUCY2F,ACSL4,AMMECR1,RTL9,CHRDL1,DCX,ALG13,TRPC5,XACT,IL1RAPL2,NRK,MORC4,TMEM164,PAK3
girirajan_12_ASD/DD/ID_discovery_cases-case2231
NA
Unknown
Unknown
Unknown
RPSAP59,BEX4,TCEAL8,TCEAL5,BEX2,TCEAL7,TCEAL9,BEX3,TCEAL3-AS1,MORF4L2-AS1,TMEM31,RNA5SP511,TMSB15B-AS1,DPPA3P1,H2BFWT,H2BFM,ZCCHC18,PHBP10,RPL18AP14,TEX13A,KCTD9P2,RNU6-207P,NAP1L4P2,SERPINA7P1,MIR548AN,RIPPLY1,EEF1A1P40,MYCLP1,DNAJA1P3,KRT18P49,NLRP3P1,TEX13B,IRS4,RNU6-309P,KCNE5,RPS5P7,MIR652,MIR3978,SNORD96B,AMMECR1-IT1,GNG5P2,TDGF1P3,FCF1P4,RNU6-496P,HMGB1P12,SERTM2,EIF4BP7,RPL18AP15,RNA5SP512,ALG13-AS1,DPRXP7,RTL4,HMGB3P30,MIR4329,RN7SL266P,RNU6-1015P,QTRT1P1,RNU1-57P,RN7SL93P,RAB40A,TCEAL4,TCEAL3,TCEAL1,GLRA4,PLP1,RAB9B,SLC25A53,FAM199X,ESX1,RNF128,CLDN2,NUP62CL,FRMPD3-AS1,FRMPD3,PRPS1,NCBP2L,VSIG1,PSMD10,NXT2,GLUD1P9,CAPN6,TRPC5OS,LHFPL1,AMOT,MORF4L2,TMSB15B,SERPINA7,TBC1D8B,RBM41,PIH1D3,TSC22D3,MID2,ATG4A,COL4A6,COL4A5,GUCY2F,ACSL4,AMMECR1,RTL9,CHRDL1,DCX,ALG13,TRPC5,XACT,IL1RAPL2,NRK,MORC4,TMEM164,PAK3
girirajan_12_ASD/DD/ID_discovery_cases-case2232
NA
Unknown
Unknown
Unknown
RPSAP59,BEX4,TCEAL8,TCEAL5,BEX2,TCEAL7,TCEAL9,BEX3,TCEAL3-AS1,MORF4L2-AS1,TMEM31,RNA5SP511,TMSB15B-AS1,DPPA3P1,H2BFWT,H2BFM,ZCCHC18,PHBP10,RPL18AP14,TEX13A,KCTD9P2,RNU6-207P,NAP1L4P2,SERPINA7P1,MIR548AN,RIPPLY1,EEF1A1P40,MYCLP1,DNAJA1P3,KRT18P49,NLRP3P1,TEX13B,IRS4,RNU6-309P,KCNE5,RPS5P7,MIR652,MIR3978,SNORD96B,AMMECR1-IT1,GNG5P2,TDGF1P3,FCF1P4,RNU6-496P,HMGB1P12,SERTM2,EIF4BP7,RPL18AP15,RNA5SP512,ALG13-AS1,DPRXP7,RTL4,HMGB3P30,MIR4329,RN7SL266P,RNU6-1015P,QTRT1P1,RNU1-57P,RN7SL93P,RAB40A,TCEAL4,TCEAL3,TCEAL1,GLRA4,PLP1,RAB9B,SLC25A53,FAM199X,ESX1,RNF128,CLDN2,NUP62CL,FRMPD3-AS1,FRMPD3,PRPS1,NCBP2L,VSIG1,PSMD10,NXT2,GLUD1P9,CAPN6,TRPC5OS,LHFPL1,AMOT,MORF4L2,TMSB15B,SERPINA7,TBC1D8B,RBM41,PIH1D3,TSC22D3,MID2,ATG4A,COL4A6,COL4A5,GUCY2F,ACSL4,AMMECR1,RTL9,CHRDL1,DCX,ALG13,TRPC5,XACT,IL1RAPL2,NRK,MORC4,TMEM164,PAK3
girirajan_12_ASD/DD/ID_discovery_cases-case2233
NA
Unknown
Unknown
Unknown
RPSAP59,BEX4,TCEAL8,TCEAL5,BEX2,TCEAL7,TCEAL9,BEX3,TCEAL3-AS1,MORF4L2-AS1,TMEM31,RNA5SP511,TMSB15B-AS1,DPPA3P1,H2BFWT,H2BFM,ZCCHC18,PHBP10,RPL18AP14,TEX13A,KCTD9P2,RNU6-207P,NAP1L4P2,SERPINA7P1,MIR548AN,RIPPLY1,EEF1A1P40,MYCLP1,DNAJA1P3,KRT18P49,NLRP3P1,TEX13B,IRS4,RNU6-309P,KCNE5,RPS5P7,MIR652,MIR3978,SNORD96B,AMMECR1-IT1,GNG5P2,TDGF1P3,FCF1P4,RNU6-496P,HMGB1P12,SERTM2,EIF4BP7,RPL18AP15,RNA5SP512,ALG13-AS1,DPRXP7,RTL4,HMGB3P30,MIR4329,RN7SL266P,RNU6-1015P,QTRT1P1,RNU1-57P,RN7SL93P,RAB40A,TCEAL4,TCEAL3,TCEAL1,GLRA4,PLP1,RAB9B,SLC25A53,FAM199X,ESX1,RNF128,CLDN2,NUP62CL,FRMPD3-AS1,FRMPD3,PRPS1,NCBP2L,VSIG1,PSMD10,NXT2,GLUD1P9,CAPN6,TRPC5OS,LHFPL1,AMOT,MORF4L2,TMSB15B,SERPINA7,TBC1D8B,RBM41,PIH1D3,TSC22D3,MID2,ATG4A,COL4A6,COL4A5,GUCY2F,ACSL4,AMMECR1,RTL9,CHRDL1,DCX,ALG13,TRPC5,XACT,IL1RAPL2,NRK,MORC4,TMEM164,PAK3
girirajan_12_ASD/DD/ID_discovery_cases-case2234
NA
Unknown
Unknown
Unknown
RPSAP59,BEX4,TCEAL8,TCEAL5,BEX2,TCEAL7,TCEAL9,BEX3,TCEAL3-AS1,MORF4L2-AS1,TMEM31,RNA5SP511,TMSB15B-AS1,DPPA3P1,H2BFWT,H2BFM,ZCCHC18,PHBP10,RPL18AP14,TEX13A,KCTD9P2,RNU6-207P,NAP1L4P2,SERPINA7P1,MIR548AN,RIPPLY1,EEF1A1P40,MYCLP1,DNAJA1P3,KRT18P49,NLRP3P1,TEX13B,IRS4,RNU6-309P,KCNE5,RPS5P7,MIR652,MIR3978,SNORD96B,AMMECR1-IT1,GNG5P2,TDGF1P3,FCF1P4,RNU6-496P,HMGB1P12,SERTM2,EIF4BP7,RPL18AP15,RNA5SP512,ALG13-AS1,DPRXP7,RTL4,HMGB3P30,MIR4329,RN7SL266P,RNU6-1015P,QTRT1P1,RNU1-57P,RN7SL93P,RAB40A,TCEAL4,TCEAL3,TCEAL1,GLRA4,PLP1,RAB9B,SLC25A53,FAM199X,ESX1,RNF128,CLDN2,NUP62CL,FRMPD3-AS1,FRMPD3,PRPS1,NCBP2L,VSIG1,PSMD10,NXT2,GLUD1P9,CAPN6,TRPC5OS,LHFPL1,AMOT,MORF4L2,TMSB15B,SERPINA7,TBC1D8B,RBM41,PIH1D3,TSC22D3,MID2,ATG4A,COL4A6,COL4A5,GUCY2F,ACSL4,AMMECR1,RTL9,CHRDL1,DCX,ALG13,TRPC5,XACT,IL1RAPL2,NRK,MORC4,TMEM164,PAK3
Controls
No Control Data Available
No Animal Model Data Available