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M_MECP2_8_CKD_HM_PYRAMIDALN-L2-3
Model Details
Change
No Change
Phenotypic Profile
Category
Entity
Quantity
Experimental Paradigm
Age at Testing
Neurophysiology
Synaptic transmission: excitatory
1
Decreased
View More
Description:
Decreased excitatory input to neurons in l2/3 and l3/5a
Exp Paradigm:
Glutamate uncaging and laser scanning photostimulation (lsps) of cortical slices and recording on neuron whose inputs are mapped
Laser scanning photostimulation
Unreported
Description:
Decreased excitatory input to neurons in l2/3 and l3/5a
Exp Paradigm:
Glutamate uncaging and laser scanning photostimulation (lsps) of cortical slices and recording on neuron whose inputs are mapped
Neurophysiology
Action potential property: firing rate
1
No change
Whole-cell patch clamp
3-4 weeks
Neurophysiology
Epsp-spike relationship
1
No change
Whole-cell patch clamp
3-4 weeks
Neurophysiology
Intrinsic membrane properties
1
No change
Whole-cell patch clamp
3-4 weeks
Neurophysiology
Membrane potential
1
No change
Whole-cell patch clamp
3-4 weeks
Neurophysiology
Synaptic transmission: inhibitory
1
No change
Laser scanning photostimulation
Unreported
Not Reported:
Circadian sleep/wake cycle
,
Communications
,
Developmental profile
,
Emotion
,
Immune response
,
Learning & memory
,
Maternal behavior
,
Molecular profile
,
Motor phenotype
,
Neuroanatomy / ultrastructure / cytoarchitecture
,
Physiological parameters
,
Repetitive behavior
,
Seizure
,
Sensory
,
Social behavior
,
References:
1:
Wood L , et al. 2009
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