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M_MECP2_50_KI_HE_STOP_REINSTATE-DNIC
Model Details
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Phenotypic Profile
Category Entity Quantity Experimental Paradigm Age at Testing
Motor phenotype Limb posture1
Ameliorated
Description: Mecp2-dnic-stop-creer mutant mice showed decreased in phenotypic severity scores compared to mecp2-dnic-stop mutant controls. specifically, mecp2-dnic-stop-creer mutant mice showed relief in a number of phenotypic symptoms (activity, gait, clasping, tremor, breathing) of mecp2-dnic-stop mutant controls.
Exp Paradigm: NA

General observations 4-28 weeks
Motor phenotype General locomotor activity1
Ameliorated
Description: Mecp2-dnic-stop-creer mutant mice showed decreased in phenotypic severity scores compared to mecp2-dnic-stop mutant controls. specifically, mecp2-dnic-stop-creer mutant mice showed relief in a number of phenotypic symptoms (activity, gait, clasping, tremor, breathing) of mecp2-dnic-stop mutant controls.
Exp Paradigm: NA

General observations 4-28 weeks
Motor phenotype Gait1
Ameliorated
Description: Mecp2-dnic-stop-creer mutant mice showed decreased in phenotypic severity scores compared to mecp2-dnic-stop mutant controls. specifically, mecp2-dnic-stop-creer mutant mice showed relief in a number of phenotypic symptoms (activity, gait, clasping, tremor, breathing) of mecp2-dnic-stop mutant controls.
Exp Paradigm: NA

General observations 4-28 weeks
Motor phenotype Tremor1
Ameliorated
Description: Mecp2-dnic-stop-creer mutant mice showed decreased in phenotypic severity scores compared to mecp2-dnic-stop mutant controls. specifically, mecp2-dnic-stop-creer mutant mice showed relief in a number of phenotypic symptoms (activity, gait, clasping, tremor, breathing) of mecp2-dnic-stop mutant controls.
Exp Paradigm: NA

General observations 4-28 weeks
Developmental profile Mortality/lethality1
Restored
Description: Mecp2-dnic-stop-creer mutant mice showed reduced mortality in mecp2-dnic-stop mutant mice.
Exp Paradigm: NA

General observations 0-28 weeks
Not Reported: Circadian sleep/wake cycle,  Communications,  Emotion,  Immune response,  Learning & memory,  Maternal behavior,  Molecular profile,  Neuroanatomy / ultrastructure / cytoarchitecture,  Neurophysiology,  Physiological parameters,  Repetitive behavior,  Seizure,  Sensory,  Social behavior,  
 
References: 1:  Tillotson R , et al. 2017
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