M_MECP2_5.2_KO_HT_CORTISONE-H - Phenotypic Profile

M_MECP2_5.2_KO_HT_CORTISONE-H
Model Details

	Change
	No Change

Phenotypic Profile

Category

Entity

Quantity

Experimental Paradigm

Age at Testing

Motor phenotype

Clasping reflex¹

Increased

Description: Abnormal hindlimb clasping is displayed significantly earlier after treatment with cortisone
Exp Paradigm: General observations in separate cage

General observations

0-7.5 months

Molecular profile

Gene expression¹

Increased

Description: Increased expression of genes fkbp5 and sgk1 in brain is refractoryto the treatment (higher than one without the treatment)
Exp Paradigm: Fkbp5 and sgk1 gene expression

Quantitative pcr (qrt-pcr)

5 weeks

Developmental profile

Mortality/lethality¹

No change

General observations

5.5 months

Not Reported:

Circadian sleep/wake cycle, Communications, Emotion, Immune response, Learning & memory, Maternal behavior, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, Sensory, Social behavior,

References:

1: Braun S , et al. 2011

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