| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Motor phenotype |
General locomotor activity1 |
Decreased
Description: Decreased general locomotor activity as indicated by decreased travelled distance
Exp Paradigm: Open field test
|
Open field test |
6-8 weeks |
| |
|
Description: Decreased general locomotor activity as indicated by decreased travelled distance
Exp Paradigm: Open field test |
|
|
| Motor phenotype |
Motor coordination and balance1 |
Decreased
Description: Decreased motor coordination indicated by rotarod test performance
Exp Paradigm: Rotarod test
|
Accelerating rotarod test |
6-8 weeks |
| |
|
Description: Decreased motor coordination indicated by rotarod test performance
Exp Paradigm: Rotarod test |
|
|
| Developmental profile |
Mortality/lethality1 |
Increased
Description: Decreased lifespan is refractoryto the treatment (31% decrease in mean life expectancy of mecp2/y mice)
Exp Paradigm: General observations
|
General observations |
0-4.5 months |
| |
|
Description: Decreased lifespan is refractoryto the treatment (31% decrease in mean life expectancy of mecp2/y mice)
Exp Paradigm: General observations |
|
|
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Emotion, Immune response, Learning & memory, Maternal behavior, Molecular profile, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, Sensory, Social behavior, |
