| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Motor phenotype |
Motor coordination and balance1 |
Decreased
Description: Mecp2-dnic mutant mice showed a decrease in latency to fall from the accelerating rotarod compared to controls.
Exp Paradigm: NA
|
Accelerating rotarod test |
20 weeks |
| |
|
Description: Mecp2-dnic mutant mice showed a decrease in latency to fall from the accelerating rotarod compared to controls.
Exp Paradigm: NA |
|
|
| Motor phenotype |
Limb posture1 |
Abnormal
Description: Mecp2-dnic mutant mice showed partial hindlimb clasping behavior compared to controls.
Exp Paradigm: NA
|
General observations |
4-52 weeks |
| |
|
Description: Mecp2-dnic mutant mice showed partial hindlimb clasping behavior compared to controls.
Exp Paradigm: NA |
|
|
| Motor phenotype |
Gait1 |
Abnormal
Description: Mecp2-dnic mutant mice showed gait abnormalities compared to controls.
Exp Paradigm: NA
|
General observations |
4-52 weeks |
| |
|
Description: Mecp2-dnic mutant mice showed gait abnormalities compared to controls.
Exp Paradigm: NA |
|
|
| Developmental profile |
Size/growth1 |
Decreased
Description: Mecp2-dnic mutant mice showed significant decrease in growth compared to controls.
Exp Paradigm: NA
|
Body weight measurement |
4-52 weeks |
| |
|
Description: Mecp2-dnic mutant mice showed significant decrease in growth compared to controls.
Exp Paradigm: NA |
|
|
| Emotion |
Anxiety1 |
Decreased
Description: Mecp2-dnic mutant mice spent less time in the closed arms and more time in the center of the elevated plus maze compared to controls. however, mecp2-dnic mutant mice showed no difference in time spent in the open arms of the elevated plus maze compared to controls.
Exp Paradigm: NA
|
Elevated plus maze test |
20 weeks |
| |
|
Description: Mecp2-dnic mutant mice spent less time in the closed arms and more time in the center of the elevated plus maze compared to controls. however, mecp2-dnic mutant mice showed no difference in time spent in the open arms of the elevated plus maze compared to controls.
Exp Paradigm: NA |
|
|
| Molecular profile |
Targeted expression1 |
Decreased
Description: Mecp2-dnic mutant mice showed a reduction in expression levels of the truncated protein in the brain (~50%) and in neurons (~40%) compared to controls.
Exp Paradigm: NA
|
Western blot |
6-13 weeks |
| |
|
Description: Mecp2-dnic mutant mice showed a reduction in expression levels of the truncated protein in the brain (~50%) and in neurons (~40%) compared to controls.
Exp Paradigm: NA |
|
|
| Developmental profile |
Mortality/lethality1 |
No change |
General observations |
0-52 weeks |
| Emotion |
Anxiety1 |
No change |
Open field test |
20 weeks |
| Molecular profile |
Targeted expression1 |
No change |
Quantitative pcr (qrt-pcr) |
11 weeks |
| Motor phenotype |
General locomotor activity: ambulatory activity1 |
No change |
Open field test |
20 weeks |
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Immune response, Learning & memory, Maternal behavior, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, Sensory, Social behavior, |
