| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Motor phenotype |
Motor coordination and balance1 |
Refractory
Description: Mecp2 reinstatement in the somatosensory neurons does not improver performance or latency to fall off the accelerating rotarod
Exp Paradigm: NA
|
Accelerating rotarod test |
6-8 weeks |
| |
|
Description: Mecp2 reinstatement in the somatosensory neurons does not improver performance or latency to fall off the accelerating rotarod
Exp Paradigm: NA |
|
|
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Brain size1 |
Refractory
Description: Mecp2 reinstatement in the somatosensory neurons does not increase brain size and it remains smaller to controls
Exp Paradigm: NA
|
Histology |
3-6 months |
| |
|
Description: Mecp2 reinstatement in the somatosensory neurons does not increase brain size and it remains smaller to controls
Exp Paradigm: NA |
|
|
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Synaptic neuroreceptors1 |
Restored
Description: Mecp2 reinstatement in the somatosensory neurons restores the number of puncta co-expressing gabrb3 and vglut1 to control levels
Exp Paradigm: NA
|
Immunohistochemistry |
3-6 months |
| |
|
Description: Mecp2 reinstatement in the somatosensory neurons restores the number of puncta co-expressing gabrb3 and vglut1 to control levels
Exp Paradigm: NA |
|
|
| Neurophysiology |
Dorsal root potential (drp)1 |
Restored
Description: Mecp2 reinstatement in the somatosensory neurons restores dorsal root potential that implies pad and presynaptic inhibition in the spinal cord are also corrected
Exp Paradigm: NA
|
Whole-cell patch clamp |
P14-p19 |
| |
|
Description: Mecp2 reinstatement in the somatosensory neurons restores dorsal root potential that implies pad and presynaptic inhibition in the spinal cord are also corrected
Exp Paradigm: NA |
|
|
| Sensory |
Sensorimotor gating1 |
Refractory
Description: Mecp2 reinstatement in the somatosensory neurons does not restore sensorimotor gating in prepulse inhibition
Exp Paradigm: NA
|
Prepulse inhibition |
6-8 weeks |
| |
|
Description: Mecp2 reinstatement in the somatosensory neurons does not restore sensorimotor gating in prepulse inhibition
Exp Paradigm: NA |
|
|
| Sensory |
Tactile memory1 |
Restored
Description: Mecp2 reinstatement in the somatosensory neurons restore glabrous skin tactile discrimination and memory and rescued mice perform like controls in textured nort
Exp Paradigm: NA
|
Textured novel object recognition test (t-nort) |
6-8 weeks |
| |
|
Description: Mecp2 reinstatement in the somatosensory neurons restore glabrous skin tactile discrimination and memory and rescued mice perform like controls in textured nort
Exp Paradigm: NA |
|
|
| Sensory |
Startle response: acoustic stimulus1 |
Refractory
Description: Startle response: acoustic stimulus remains impaired after mecp2 reinstatement in mecp2 stop (null) mice
Exp Paradigm: NA
|
Startle response test |
6-8 weeks |
| |
|
Description: Startle response: acoustic stimulus remains impaired after mecp2 reinstatement in mecp2 stop (null) mice
Exp Paradigm: NA |
|
|
| Sensory |
Sensorimotor gating: tactile cue1 |
Restored
Description: Mecp2 reinstatement in the somatosensory neurons restores sensotimotor gating and normal response to startle following a prepulse of air puff
Exp Paradigm: NA
|
Prepulse inhibition |
6-8 weeks |
| |
|
Description: Mecp2 reinstatement in the somatosensory neurons restores sensotimotor gating and normal response to startle following a prepulse of air puff
Exp Paradigm: NA |
|
|
| Social behavior |
Nest building behavior1 |
Ameliorated
Description: Mecp2 reinstatement only in the somatosensory neurons ameliorates nest building behavior
Exp Paradigm: NA
|
Nest building assay |
6-8 weeks |
| |
|
Description: Mecp2 reinstatement only in the somatosensory neurons ameliorates nest building behavior
Exp Paradigm: NA |
|
|
| Social behavior |
Social memory1 |
Restored
Description: Mecp2 reinstatement in the somatosensory neurons restores preference for stranger mouse over familiar mouse
Exp Paradigm: NA
|
Three-chamber social approach test |
6-8 weeks |
| |
|
Description: Mecp2 reinstatement in the somatosensory neurons restores preference for stranger mouse over familiar mouse
Exp Paradigm: NA |
|
|
| Social behavior |
Social dominance1 |
Restored
Description: Mecp2 reinstatement in the somatosensory neurons normalizes dominance and these mice have significantly increased percenteage of wins compared to mecp2 stop mice
Exp Paradigm: NA
|
Tube test of social dominance |
6-8 weeks |
| |
|
Description: Mecp2 reinstatement in the somatosensory neurons normalizes dominance and these mice have significantly increased percenteage of wins compared to mecp2 stop mice
Exp Paradigm: NA |
|
|
| Social behavior |
Social approach1 |
Restored
Description: Mecp2 reinstatement in the somatosensory neurons restores social approach and preference for stranger mouse over object
Exp Paradigm: NA
|
Three-chamber social approach test |
6-8 weeks |
| |
|
Description: Mecp2 reinstatement in the somatosensory neurons restores social approach and preference for stranger mouse over object
Exp Paradigm: NA |
|
|
| Emotion |
Habituation to aversive stimuli1 |
Restored
Description: Mecp2 reinstatement in the somatosensory neurons habituate normally to aversive stimuli unlike mecp2 stop mice and similar to controls
Exp Paradigm: NA
|
Startle response test |
6-8 weeks |
| |
|
Description: Mecp2 reinstatement in the somatosensory neurons habituate normally to aversive stimuli unlike mecp2 stop mice and similar to controls
Exp Paradigm: NA |
|
|
| Emotion |
Anxiety1 |
Restored
Description: Mecp2 reinstatement in the somatosensory neurons restores anxiety to normal levels determined by comparable time spent in center of the of to controls
Exp Paradigm: Open field test
|
Open field test |
6-8 weeks |
| |
|
Description: Mecp2 reinstatement in the somatosensory neurons restores anxiety to normal levels determined by comparable time spent in center of the of to controls
Exp Paradigm: Open field test |
|
|
| Emotion |
Anxiety1 |
Restored
Description: Mecp2 reinstatement in the somatosensory neurons restores anxiety to normal levels determined by comparable time spent in center of the of to controls
Exp Paradigm: Elevated plus maze test
|
Elevated plus maze test |
6-8 weeks |
| |
|
Description: Mecp2 reinstatement in the somatosensory neurons restores anxiety to normal levels determined by comparable time spent in center of the of to controls
Exp Paradigm: Elevated plus maze test |
|
|
| Learning & memory |
Object recognition memory: long-term recall1 |
Refractory
Description: Mecp2 reinstatement in the somatosensory neurons does not correct long term recall of familiar object
Exp Paradigm: NA
|
Novel object recognition test |
6-8 weeks |
| |
|
Description: Mecp2 reinstatement in the somatosensory neurons does not correct long term recall of familiar object
Exp Paradigm: NA |
|
|
| Learning & memory |
Object recognition memory1 |
No adverse effect
Description: Mecp2 reinstatement in the somatosensory neurons does not affect object recognition memory
Exp Paradigm: NA
|
Novel object recognition test |
6-8 weeks |
| |
|
Description: Mecp2 reinstatement in the somatosensory neurons does not affect object recognition memory
Exp Paradigm: NA |
|
|
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Developmental profile, Immune response, Maternal behavior, Molecular profile, Physiological parameters, Repetitive behavior, Seizure, |
