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M_MECP2_36_TG_7X
Model Details
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Phenotypic Profile
Category Entity Quantity Experimental Paradigm Age at Testing
Motor phenotype Clasping reflex1
Increased
Description: Increased clasping reflex is observed in mecp2 tg (7x) mice
Exp Paradigm: NA

Tail suspension test 3 weeks
Seizure Seizures1
Increased
Description: Increased clonic seizures are observed by 3 weeks of age in mecp3 tg (7x) mice
Exp Paradigm: NA

General observations NA
Physiological parameters Reproductive function1
Decreased
Description: Fertility is low in mecp2 tg (7x) mice
Exp Paradigm: NA

General observations 3 weeks
Developmental profile Skeletal development1
Decreased
Description: Increased observation of kyphosis ( outward curvature of spine) starting at 2-3 weeks of age
Exp Paradigm: NA

General observations NA
Developmental profile Size/growth1
Decreased
Description: Mecp2 tg (7x) mice have smaller body size compared to controls observed by 2-3 weeks of age
Exp Paradigm: NA

General observations 3 weeks
Developmental profile Mortality/lethality1
Increased
Description: Majority of mecp2 tg(7x) mice die by 3 weeks of age
Exp Paradigm: NA

General observations 3 weeks
Not Reported: Circadian sleep/wake cycle,  Communications,  Emotion,  Immune response,  Learning & memory,  Maternal behavior,  Molecular profile,  Neuroanatomy / ultrastructure / cytoarchitecture,  Neurophysiology,  Physiological parameters,  Repetitive behavior,  Sensory,  Social behavior,  
 
References: 1:  Collins AL , et al. 2004
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