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M_MECP2_23_KI_HT_TRUNC(308)_BDE47
Model Details
Change
No Change
     
Phenotypic Profile
Category Entity Quantity Experimental Paradigm Age at Testing
Developmental profile Size/growth1
Decreased
Description: Decreased body weight is a side effect of bde-47 treatment
Exp Paradigm: General observations

General observations P8-p18
Learning & memory Spatial learning1
Decreased
Description: Decreased spatial reference memory as measured by increased latency to reach platform is a side effect of bde-47 treatment in female heterzygots
Exp Paradigm: Female mice: morris water maze task

Morris water maze test 7-12 weeks
Molecular profile Gene expression1
Increased
Description: Increased transcript levels of dna methyltransferase family of genes (dnmt1 and dnmt3a) are side effects of bde-47 treatment in female heterozygots
Exp Paradigm: Dna methyltransferase gene levels

Quantitative pcr (qrt-pcr) Unreported
Molecular profile Dna methylation1
Decreased
Description: Decreased dna methylation levels during global assessment is a side effec of bde-47 treatment in female heterzygots
Exp Paradigm: Dna methylation levels

Dot-blot analysis Unreported
Communications Ultrasonic vocalization1 No change Monitoring ultrasonic vocalizations P8-p16
Motor phenotype General locomotor activity1 No change Open field test NA
Social behavior Social approach1 No change Three-chamber social approach test 5.5-10 weeks
Social behavior Social memory1 No change Three-chamber social approach test 10 weeks
Not Reported: Circadian sleep/wake cycle,  Emotion,  Immune response,  Maternal behavior,  Neuroanatomy / ultrastructure / cytoarchitecture,  Neurophysiology,  Physiological parameters,  Repetitive behavior,  Seizure,  Sensory,  
 
References: 1:  Woods R , et al. 2012
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