| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Motor phenotype |
Motor learning1 |
Increased
Description: Increased latency to fall
|
Accelerating rotarod test |
4-5 months |
| |
|
Description: Increased latency to fall
|
|
|
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Dendritic architecture: spine turnover1 |
Decreased
Description: Increased clustered-spine stabilization
|
Two-photon microscopy |
12-14 weeks |
| |
|
Description: Increased clustered-spine stabilization
|
|
|
| Molecular profile |
Signaling: MAPK pathway |
Increased
Description: Marked hyperphosphorylation of the map kinase erk1/2 (t202/y204) upon rotarod training; basal phosphorylation state of erk was not significantly altered in mutant m1 lysates without training; level of phosphorylation did not correlate with the latency
|
|
|
| |
|
Description: Marked hyperphosphorylation of the map kinase erk1/2 (t202/y204) upon rotarod training; basal phosphorylation state of erk was not significantly altered in mutant m1 lysates without training; level of phosphorylation did not correlate with the latency
|
|
|
|
| Not Reported: |
|
