| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Motor phenotype |
Motor coordination and balance1 |
Restored
Description: Motor coordination indicated by improved rotarod test performance is restored to the same level as wild type
Exp Paradigm: Rotarod test with high-dose ru486 (210 g/ml)
|
Accelerating rotarod test |
6-8 weeks |
| |
|
Description: Motor coordination indicated by improved rotarod test performance is restored to the same level as wild type
Exp Paradigm: Rotarod test with high-dose ru486 (210 g/ml) |
|
|
| Motor phenotype |
General locomotor activity1 |
Ameliorated
Description: General locomotor activity as measured by total distance travelled is improved by the treatment although the extent is not statistically significant
Exp Paradigm: Open field test with high-dose ru486 (210 g/ml)
|
Open field test |
6-8 weeks |
| |
|
Description: General locomotor activity as measured by total distance travelled is improved by the treatment although the extent is not statistically significant
Exp Paradigm: Open field test with high-dose ru486 (210 g/ml) |
|
|
| Motor phenotype |
Clasping reflex1 |
Ameliorated
Description: Abnormal hindlimb clasping is partially restored indicated by significantly longer clasping-free time (68%/4 weeks longer)
Exp Paradigm: General observations in separate cage
|
General observations |
0-14 weeks |
| |
|
Description: Abnormal hindlimb clasping is partially restored indicated by significantly longer clasping-free time (68%/4 weeks longer)
Exp Paradigm: General observations in separate cage |
|
|
| Developmental profile |
Mortality/lethality1 |
Refractory
Description: Decrease life span is refractoryto the treatment
Exp Paradigm: General observations
|
General observations |
0-4.5 months |
| |
|
Description: Decrease life span is refractoryto the treatment
Exp Paradigm: General observations |
|
|
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Emotion, Immune response, Learning & memory, Maternal behavior, Molecular profile, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, Sensory, Social behavior, |
