M_MECP2_46_KI_HE_TRUNC(N-TERM) - Phenotypic Profile

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M_MECP2_46_KI_HE_TRUNC(N-TERM)
Model Details

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Category	Entity	Quantity	Experimental Paradigm	Age at Testing
Phenotypic Profile
Developmental profile	Mortality/lethality¹	No change	General observations	0-52 weeks
Developmental profile	Size/growth¹	No change	Body weight measurement	4-52 weeks
Emotion	Anxiety¹	No change	Elevated plus maze test	20 weeks
Emotion	Anxiety¹	No change	Open field test	20 weeks
Molecular profile	Targeted expression¹	No change	Western blot	6-13 weeks
Motor phenotype	General locomotor activity: ambulatory activity¹	No change	Open field test	20 weeks
Motor phenotype	Motor coordination and balance¹	No change	Accelerating rotarod test	20 weeks

Not Reported:	Circadian sleep/wake cycle, Communications, Immune response, Learning & memory, Maternal behavior, Neuroanatomy / ultrastructure / cytoarchitecture, Neurophysiology, Physiological parameters, Repetitive behavior, Seizure, Sensory, Social behavior,

References:

1: Tillotson R , et al. 2017


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