| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Neurophysiology |
Synaptic plasticity: hippocampal LTP1 |
Increased
Description: Increased ltp of population spikes at perforant path-to-granule cell (pp-gc) synapses induced by weak theta-burst stimulation (tbs) but not futher increased by a strong theta-burst stimulation; no change in spike amplitude potentiation following the strong tbs; no significant differences in the potentiation of the fepsp slope in the first 30 min after weak tbs indicating no enhancement of synaptic efficiency
|
Whole-cell patch clamp |
2-5 months |
| |
|
Description: Increased ltp of population spikes at perforant path-to-granule cell (pp-gc) synapses induced by weak theta-burst stimulation (tbs) but not futher increased by a strong theta-burst stimulation; no change in spike amplitude potentiation following the strong tbs; no significant differences in the potentiation of the fepsp slope in the first 30 min after weak tbs indicating no enhancement of synaptic efficiency
|
|
|
| Neurophysiology |
Network excitability1 |
Decreased
Description: Decreased excitability and impairment of epsp-population spike (eā??s) coupling, indicating mutants need a stronger synaptic input to produce a similar spike response
|
Whole-cell patch clamp |
2-5 months |
| |
|
Description: Decreased excitability and impairment of epsp-population spike (eā??s) coupling, indicating mutants need a stronger synaptic input to produce a similar spike response
|
|
|
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Neuronal number: Excitatory neurons1 |
No change |
Transmission electron microscopy (TEM) |
2-5 months |
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Synapse density: Excitatory1 |
No change |
Whole-cell patch clamp |
2-5 months |
| Neurophysiology |
Action potential property: amplitude1 |
No change |
Whole-cell patch clamp |
2-5 months |
| Neurophysiology |
EPSP-spike relationship1 |
No change |
Whole-cell patch clamp |
2-5 months |
| Neurophysiology |
Population spikes1 |
No change |
Whole-cell patch clamp |
2-5 months |
| Neurophysiology |
Presynaptic function: paired-pulse depression (PPD)1 |
No change |
Whole-cell patch clamp |
2-5 months |
| Neurophysiology |
Presynaptic function: paired-pulse facilitation1 |
No change |
Whole-cell patch clamp |
2-5 months |
| Neurophysiology |
Stimulus-spike relationship: inhibitory1 |
No change |
Whole-cell patch clamp |
2-5 months |
| Neurophysiology |
Synaptic transmission: excitatory1 |
No change |
Whole-cell patch clamp |
2-5 months |
|
| Not Reported: |
|
