| Phenotypic Profile |
| Category |
Entity |
Quantity |
Experimental Paradigm |
Age at Testing |
| Motor phenotype |
Self grooming: artificial stress evoked1 |
Increased
Description: Increased self grooming behavior after their snout was sprayed with water mist
Exp Paradigm: Aversive stimulus on head of the test mouse
|
Splash test to evoke grooming behavior |
Unreported |
| |
|
Description: Increased self grooming behavior after their snout was sprayed with water mist
Exp Paradigm: Aversive stimulus on head of the test mouse |
|
|
| Motor phenotype |
General locomotor activity: ambulatory activity1 |
Decreased
Description: Decreased horizontal ambulatory cage activity during sunrise period
Exp Paradigm: Cage activity recording during 23h period
|
Home cage behavior |
Unreported |
| |
|
Description: Decreased horizontal ambulatory cage activity during sunrise period
Exp Paradigm: Cage activity recording during 23h period |
|
|
| Neuroanatomy / Ultrastructure / Cytoarchitecture |
Brain size1 |
Decreased
Description: Decreased brain weight
Exp Paradigm: General observations
|
General observations |
12 weeks |
| |
|
Description: Decreased brain weight
Exp Paradigm: General observations |
|
|
| Neurophysiology |
Synaptic plasticity: hippocampal ltp1 |
Increased
Description: Increased ltp as indicated by significant higher initial magnitude of potentiation
Exp Paradigm: Extracellular recordings in ca1 region of hippocampus
|
Field potential recordings |
Unreported |
| |
|
Description: Increased ltp as indicated by significant higher initial magnitude of potentiation
Exp Paradigm: Extracellular recordings in ca1 region of hippocampus |
|
|
| Social behavior |
Social interaction1 |
Decreased
Description: Decreased social behavior indicated by equal time spent in chamber with unfamiliar mouse and empty cage
Exp Paradigm: Sociability and preference for social novelty (spsn) test
|
Three-chamber social approach test |
Unreported |
| |
|
Description: Decreased social behavior indicated by equal time spent in chamber with unfamiliar mouse and empty cage
Exp Paradigm: Sociability and preference for social novelty (spsn) test |
|
|
| Developmental profile |
Size/growth1 |
Decreased
Description: Decreased body weight
Exp Paradigm: General observations
|
General observations |
12 weeks |
| |
|
Description: Decreased body weight
Exp Paradigm: General observations |
|
|
| Learning & memory |
Spatial reference memory1 |
Decreased
Description: Decreased spatial reference memory indicated by failure to show preference for target quadrant
Exp Paradigm: Morris water maze test
|
Morris water maze test |
Unreported |
| |
|
Description: Decreased spatial reference memory indicated by failure to show preference for target quadrant
Exp Paradigm: Morris water maze test |
|
|
| Learning & memory |
Cued or contextual fear conditioning: memory of context1 |
Increased
Description: Increased contextal and conditioned fear response indicated by increased percentage of freezing and
Exp Paradigm: Contextual fear conditioning test with aversive footshock conditioning
|
Fear conditioning test |
Unreported |
| |
|
Description: Increased contextal and conditioned fear response indicated by increased percentage of freezing and
Exp Paradigm: Contextual fear conditioning test with aversive footshock conditioning |
|
|
| Molecular profile |
Protein expression level evidence1 |
Increased
Description: Increased levels of bdnf in hippocampus
Exp Paradigm: Bdnf levels
|
Western blot |
8 weeks |
| |
|
Description: Increased levels of bdnf in hippocampus
Exp Paradigm: Bdnf levels |
|
|
| Molecular profile |
Gene expression1 |
Decreased
Description: Decreased expression levels of zif268 mrna in dorsomedial striatum, total hippocampal formation, ca1 region
Exp Paradigm: Zif268 mrna expression
|
In situ hybridization (ish) |
Unreported |
| |
|
Description: Decreased expression levels of zif268 mrna in dorsomedial striatum, total hippocampal formation, ca1 region
Exp Paradigm: Zif268 mrna expression |
|
|
| Emotion |
Anxiety1 |
No change |
Elevated plus maze test |
Unreported |
| Emotion |
Anxiety1 |
No change |
Open field test |
Unreported |
| Molecular profile |
Gene expression1 |
No change |
In situ hybridization (ish) |
Unreported |
| Motor phenotype |
Motor coordination and balance1 |
No change |
Accelerating rotarod test |
Unreported |
| Motor phenotype |
Swimming ability1 |
No change |
Swim test |
Unreported |
| Neurophysiology |
Synaptic plasticity1 |
No change |
Field potential recordings |
Unreported |
| Neurophysiology |
Synaptic transmission1 |
No change |
Field potential recordings |
Unreported |
| Sensory |
Foot shock sensitivity1 |
No change |
Foot shock test |
Unreported |
| Sensory |
Hearing1 |
No change |
NA |
Unreported |
| Sensory |
Sensorimotor gating1 |
No change |
Prepulse inhibition |
Unreported |
| Sensory |
Startle response: acoustic stimulus1 |
No change |
Acoustic startle reflex test |
Unreported |
| Social behavior |
Social interaction1 |
No change |
Three-chamber social approach test |
Unreported |
|
| Not Reported: |
Circadian sleep/wake cycle, Communications, Immune response, Maternal behavior, Physiological parameters, Repetitive behavior, Seizure, |
