Cognitive flexibility

(AM700000)

Ability to restructure previously learned concepts with new information to manage new situations, for example, reversal learning

Water T-maze test; Morris water maze test; Radial maze test; Spatial discrimination assay; Conflict place avoidance test; Barnes maze test; Operant conditioning paradigm; T-maze test; Fear conditioning test; Two-choice digging test; Water Y-maze; Puzzle box test; Running wheel test; Clock-maze test; Place learning test

Cognitive flexibility: associative learning

(AM700001)

Ability to restructure previously learned concepts with new information to manage new situations; in relation to the acquisition of associative memory, which establishes a relationship between two stimuli, or between a stimulus and a behavioral response

Conditioned place preference test; Fear conditioning test; Set-shifting task; Hole-board test; T-maze test; Morris water maze test

Conditioned taste aversion

(AM700002)

Classical conditioned avoidance of certain foods (CS) following a previous experience of malaise

Conditioned taste aversion test

Cued or contextual fear conditioning

(AM700003)

Storage of information that establishes an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue, or a neutral environment)

Fear conditioning test; Forced swim test; Passive avoidance test; Active avoidance test

Cued or contextual fear conditioning: context discrimination

(AM700004)

Ability to discriminate a novel environment from a familiar environment (the conditioned stimulus or CS) where there was a learned association with an aversive experience (the unconditioned stimulus or US, usually a shock)

Fear conditioning test

Cued or contextual fear conditioning: memory of context

(AM700005)

Storage of information that establishes an association, lasting days, between an aversive experience (the unconditioned stimulus or US, usually a shock) and a neutral, unchanging environment (the conditioned stimulus or CS)

Fear conditioning test; Open field test; Novel cage test; Foot shock test

Cued or contextual fear conditioning: memory of context: long term recall

(AM700006)

Ability to establish a remote memory, lasting weeks, of an association between an aversive experience (the unconditioned stimulus or US, usually a shock) and a neutral, unchanging environment (the conditioned stimulus or CS)

Fear conditioning test

Cued or contextual fear conditioning: memory of cue

(AM700007)

Storage of information that establishes an association, lasting days, between an aversive experience (the unconditioned stimulus or US, usually a shock) and a neutral auditory cue (the conditioned stimulus or CS)

Fear conditioning test; Operant self-learning paradigm; Passive avoidance test; Active avoidance test; Conditioned place preference test

Cued or contextual fear conditioning: passive avoidance

(AM700008)

Storage of information that establishes a relationship between the environment and an unpleasant or punishing stimulus, such as a shock, applied with a prolonged latency

Passive avoidance test; Open field test

Cued or contextual fear conditioning: trace fear conditioning

(AM700009)

Storage of information that establishes an association between an aversive experience (the unconditioned stimulus or US, usually a shock) and a neutral auditory cue (the conditioned stimulus or CS) where there is an empty interval (trace) that separates the cessation of the CS from the onset of the US

Fear conditioning test

Cued or contextual fear conditioning: latent inhibition

(AM700010)

Impairment in a conditioned response seen after repeated unpaired presentations of the conditioned stimulus (CS) prior to pairing it with the unconditioned stimulus (US)

Fear conditioning test

Eye blink conditioning

(AM700011)

Ability to learn to blink in anticipation of an aversive stimulus (e.g., an air puff to the eyelid) following repeated pairings with a neutral stimulus (e.g., a tone), at a precise timing between the conditioned and unconditioned stimuli

Eyeblink conditioning

Object recognition memory

(AM700012)

Ability to recognize objects previously encountered, usually measured by decreased exploration of familiar objects

Novel object recognition test; Running wheel test; General observations; Object-place recognition test; Open field test; Visual lateralization novel object laterization (VLNOR); Grooming behavior assessments; Reciprocal social interaction test; Novel object exploration test

Olfactory learning and memory

(AM700013)

Ability to exhibit a differential response to olfactory stimuli that is achieved by the reinforcement of the desired response for each particular olfactory stimulus

Olfactory habituation-dishabituation test; Hole-board test; Fear conditioning test; Appetitive odor preference test; Operant conditioning paradigm

Procedural learning

(AM700014)

Acquisition of implicit memory, that which does not require conscious attention for recall, for example, habits, perceptual or motor strategies, associative and non-associative conditioning

Active avoidance test; Running wheel test; Accelerating rotarod test

Cued or contextual fear conditioning: memory of cue: long term recall

(AM700015)

Ability to establish a remote memory, lasting weeks, of an association between an aversive experience (the unconditioned stimulus or US, usually a shock) and a neutral auditory cue (the conditioned stimulus or CS)

Fear conditioning test

Reward reinforced choice behavior

(AM700016)

Learned behavior of making a choice that has a higher probability of increased reward

T-maze test; Y-maze test; Operant conditioning paradigm; Biological motion perception test; Conditioned place preference test; Five-choice serial reaction time test (5-CSRTT); Two-choice digging test; Delayed non-match to sample T-maze test; Barnes maze test; Sucrose preference test

Spatial learning

(AM700017)

Ability to ascertain or acquire spatial location information in order to improve navigation or other behavior using such location cues

Barnes maze test; Morris water maze test; Object-place recognition test; T-maze test; Radial maze test; Water T-maze test; Water Y-maze; Clock-maze test; Labyrinth maze test; Spatial discrimination assay; Operant self-learning paradigm

Spatial reference memory

(AM700018)

Ability to recall spatial location information from previous encounters or training sessions in order to navigate or perform other behavior using such location cues

Morris water maze test; T-maze test; Barnes maze test; Object-place recognition test; Radial maze test; Water Y-maze; Open field test; Passive avoidance test; Y-maze test; Plus-shaped water maze test

Spatial working memory

(AM700019)

Ability to spontaneously process spatial location information in order to navigate or perform other behavior using such location cues, without previous encounters or training at that location

Morris water maze test; Radial maze test; Water Y-maze test; Y-maze test; T-maze test; Barnes maze test; Delayed non-match to place test; Water T-maze test; Nose poke test; Eight-arm radial maze test; Object-place recognition test

Swim distance

(AM700020)

Total distance swum by the test mouse, usually in the Morris water maze

Eye blink conditioning: extinction and reactivation

(AM700021)

Ability to extinguish or forget a previously learned eye blink conditioned response (CR) after being exposed to conditioned stimulus (CS) without unconditioned stimulus (US), sometimes followed by reactivation or relearning of the CR to the same or modified CS

Eyeblink conditioning

Stimulus-response learning

(AM700022)

Ability to learn to perform a particular behavior when a certain stimulus is present, for example using a proximal visual cue to complete a task, as opposed to distal contextual cues

Barnes maze test; Sucrose preference test

Episodic-like memory

(AM700023)

Temporal and spatial recall required for tasks with long delay

Morris water maze test; Radial maze test; Puzzle box test; Object-place recognition test

Extinction of fear memory

(AM700024)

Ability to extinguish aversive memories associated with a traumatic incident

Fear conditioning test

Cognitive flexibility: distractor suppression

(AM700025)

Differentiating distracting stimuli from relevant stimuli during training to learn a task, similar to attention tasks in people

Operant conditioning paradigm

Object recognition memory: long-term recall

(AM700026)

Ability to recognize objects previously encountered after being exposed to a familiar and a novel object following an longer interval (dependent on experimental designa nd authors), usually measured by decreased exploration of familiar objects

Visual lateralization novel object laterization (VLNOR); Novel object recognition test

Cued or contextual fear conditioning: active avoidance

(AM700027)

Fear-motivated storage of information that establishes an association between an aversive unconditional stimulus and specific cues (conditional stimulus) in a variable environment

Active avoidance test

Cued or contextual fear conditioning: memory of context: short-term memory

(AM700028)

Storage of information that establishes a short-term association, lasting minutes or hours, between an aversive experience (the unconditioned stimulus or US, usually a shock) and a neutral, unchanging environment (the conditioned stimulus or CS)

Fear conditioning test

Cued or contextual fear conditioning: memory of cue: short-term memory

(AM700029)

Storage of information that establishes a short-term association, lasting minutes or hours, between an aversive experience (the unconditioned stimulus or US, usually a shock) and a neutral auditory cue (the conditioned stimulus or CS)

Fear conditioning test

Reward reinforced choice behavior: learning

(AM700030)

T-maze test

Reward reinforced choice behavior: short-term memory

(AM700031)

T-maze test

Reward reinforced choice behavior: long-term memory

(AM700032)

T-maze test

Memory: short-term memory

(AM700033)

The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation.

Memory: medium-term memory

(AM700034)

The memory process that deals with the storage, retrieval and modification of information received at a time ago that is intermediate between that of short and long term memory (30min - 7hrs in Drosophila melanogaster).

Cognitive flexibility: associative learning: operant self-learning

(AM700035)

Operant self-learning paradigm

Cued or contextual fear conditioning: passive avoidance: odor discrimination

(AM700036)

Conditioned avoidance response to presence or specific concentration of odorants in test apparatus, following training with exposure to odorant and electric shock. Generally used in drosophila.

Extinction learning

(AM700037)

the gradual decrease in response to a conditioned stimulus that occurs when the stimulus is presented without reinforcement

Operant self-learning paradigm

Discrimination learning

(AM700038)

ability to exhibit a differential response to different stimuli that is achieved by the reinforcement of the desired response for each particular stimulus

Operant self-learning paradigm; Pairwise visual discrimination task

Reward reinforced choice behavior: cocaine

(AM700091)

Learned behavior of making a choice that has a higher probability of increased reward in the form of cocaine bedding

Operant conditioning paradigm

Reaction time: cognitive flexibility

(AM700092)

the length of time taken for an animal model to respond to a given stimulus or event in a reversal task that measures the cognitive processing agility

Reaction time: visual discrimination

(AM700093)

The length of time taken for an animal model to respond to a given stimulus or event in a visual discrimination Task that measures the cognitive processing agility

Visual discrimination learning

(AM700094)

Visual discrimination is the ability to recognize details in visual images such as those presented on a screen.

Spatial reference memory: long term recall

(AM700095)

Ability to establish a remote memory, lasting weeks, of spatial location information in order to improve navigation or other behavior using such location cues