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Animal Model >> null >> M_MECP2_9_PME Construct Details |
| Model Details :M_MECP2_9_PME
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Model Type |
Genetic
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Model Genotype |
Wildtype
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Mutation |
Mice with locus-specific methylation at the transcription start site of Mecp2 were generated using nuclease-deactivated Cas9 (dCas9) fused with DNA methyltransferase catalytic domains. DNMT3L-DNMT3A-dCas9 or DNMT3LDNMT3A-mut- dCas9 plasmids were injected into zygotes from superovulated female C57BL/6 mice. (PME, promoter methylation). |
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Allele Type |
Loss of function |
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Strain of Origin |
C57BL/6 |
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Genetic Background |
C57BL/6 |
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ES Cell Line |
Not Specified |
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Mutant ES Cell Line |
Not Specified |
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Model Source |
PMID 32015323 |
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Reference |
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