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Animal Model >> null >> M_MECP2_59_TG_2X Construct Details |
| Model Details :M_MECP2_59_TG_2X
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Model Type |
Genetic GOF
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Model Genotype |
Transgenic
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Mutation |
A full-length copy of the human gene was injected into fvb fertilized oocytes and 2-fold higher levels of protein compared to endogenous mecp2 was established. fvb-background mecp2-duplication (tg1) mice (collins et al., 2004), were crossed to c57 thy1-gfp-m homozygotes (jackson laboratory) to generate f1c57;fvb mecp2-duplication;thy1-gfpm mice and thy1-gfp-m littermate controls. [note: construct is adapted from existing m_mecp2_34_tg_2x but has a mixed background and reporter]. for motor cortex assessment animals were trained for four consecutive trials daily for four days in a row. |
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Allele Type |
Transgenic |
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Strain of Origin |
FVB |
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Genetic Background |
F1C57*FVB |
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ES Cell Line |
FVB |
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Mutant ES Cell Line |
FVB |
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Model Source |
15351775, Collins et al, 2004 |
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Reference |
Ash RT et al. 2021
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