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Animal Model >> null >> M_MECP2_58_KI_HT_GABRB3-CRE Construct Details |
| Model Details :M_MECP2_58_KI_HT_GABRB3-CRE
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Model Type |
RESCUE-Genetic
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Model Genotype |
Heterozygous
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Mutation |
Female mice heterozygous for the Mecp2 mutation R306C together with Advillin-Cre. Mecp2^R306C; Advillin-Cre female mice were intraperitoneally injected at P5 with AAV.FLEx.GABRB3.mCHERRY to restore GABRB3 expression selectively in peripheral somatosensory neurons. Wildtype controls were female Mecp2^R/R littermates injected with AAV.FLEx.GABRB3.mCHERRY. |
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Allele Type |
ASD LOF knockin |
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Strain of Origin |
Not specified |
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Genetic Background |
C57BL/6J |
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ES Cell Line |
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Mutant ES Cell Line |
129/Ola E14 TG2a mouse ES cells |
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Model Source |
Michael Greenberg; Lyst et al., 2013; PMID 23770565 |
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Reference |
Orefice LL , et al. 2019
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