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Animal Model >> null >> M_MECP2_54_CKO_HE Construct Details |
| Model Details :M_MECP2_54_CKO_HE
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Model Type |
Genetic
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Model Genotype |
Hemizygous
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Mutation |
Hemizygous mutant male mice with sensory neuron specific inducible deletion of Mecp2 (Advillin-CreERT2; Mecp2^f/y) in the early postnatal period (P5) were generated by crossing Mecp2 floxed mice with loxp sites flanking exons 3 to 4 with transgenic Advillin-CreERT2 driver mice that expresse a tamoxifen-inducible iCre recombinase directed by endogenous Avil (advillin) promoter elements in the dorsal root ganglia and sensory neurons; M_MECP2_5.13_CKO_HE |
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Allele Type |
Conditional knockout |
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Strain of Origin |
Not specified |
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Genetic Background |
C57BL/6J*129/SvEv*CD1 |
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ES Cell Line |
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Mutant ES Cell Line |
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Model Source |
Jackson Laboratory; John Wood; RRID:IMSR_JAX:032027 (Lau et al, 2011); RRID:IMSR_JAX:006847 |
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Reference |
Orefice LL , et al. 2019
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