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Animal Model >> null >> M_MECP2_5.13_CKO_HE Construct Details |
| Model Details :M_MECP2_5.13_CKO_HE
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Model Type |
Genetic
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Model Genotype |
Hemizygous
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Mutation |
Conditional deletion of exon 3- 4 of the Mecp2 gene in male mice, using Advillin-creERT2, in dorsal root ganglion and trigeminal somatosensory neurons (primary somatosensory neurons) after administration of tamoxifen to male mice for 5 days starting at P28. Authors state that Mecp2 protein is deleted from 90% of DRG neurons whereas expression in the spinal cord and brain remain normal. |
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Allele Type |
Conditional loss-of-function |
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Strain of Origin |
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Genetic Background |
129/SvEv * C57BL/6J |
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ES Cell Line |
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Mutant ES Cell Line |
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Model Source |
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Reference |
Orefice LL , et al. 2016
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