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Animal Model >> null >> M_MECP2_10_PME_HIPPOCAMPUS Construct Details |
| Model Details :M_MECP2_10_PME_HIPPOCAMPUS
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Model Type |
Genetic
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Model Genotype |
Wildtype
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Mutation |
Mice with locus-specific methylation at the transcription start site of Mecp2 in the hippocampus were generated by injecting AAV-based methylation vectors (AAV-DNMT3A-N-dCas9, AAV-AAV-C-dCas9, AAV-5U6-sgRNAs-EGFP) bilaterally into the hippocampus of adult mice. Behavioral tests were performed 4 weeks after injection. |
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Allele Type |
Loss of function |
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Strain of Origin |
C57BL/6 |
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Genetic Background |
C57BL/6 |
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ES Cell Line |
Not Specified |
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Mutant ES Cell Line |
Not Specified |
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Model Source |
PMID 32015323 |
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Reference |
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