Cntnap2 - contactin associated protein like 2 Details

Animal Model >> Cntnap2 Details

contactin associated protein-like 2

Summary

Gene Symbol

Cntnap2

Gene Name

contactin associated protein-like 2

Aliases

5430425M22Rik, Caspr2, mKIAA0868

Model Species

Mus musculus

Model Type

Genetic

Model Summary

Axon-glia interactions mediated by Cntnap2 and Tag-1 s allow myelinating glial cells to organize ion channels in the underlying axonal membrane.

Number of Reports

Number of Models

External Links

ASD-associated variation model

ASD

ASD-associated variation model

ASD Cortical dysplasia-focal epilepsy, ASD

ASD-associated variation model

ASD Cortical dysplasia-focal epilepsy, ASD ASD, Pitt-Hopkins-like syndrome 1

Animal Model >> Cntnap2 Details

contactin associated protein-like 2

Summary
Gene Symbol	Cntnap2
Gene Name	contactin associated protein-like 2
Aliases
Model Species	Rattus norvegicus
Model Type	Genetic
Model Summary	Cntnap2 knockout rats exhibit severe motor seizures, hyperactivity and increased consolidation of wakefulness and REM sleep.
Number of Reports	22
Number of Models	54
External Links
ASD-associated variation model	ASD
ASD-associated variation model	ASD Cortical dysplasia-focal epilepsy, ASD
ASD-associated variation model	ASD Cortical dysplasia-focal epilepsy, ASD ASD, Pitt-Hopkins-like syndrome 1

References
Primary	Juxtaparanodal clustering of Shaker-like K channels in myelinated axons depends on Caspr2 and TAG-1.	Poliak S , et al. 2003	12963709
Primary	Cntnap2 knockout rats and mice exhibit epileptiform activity and abnormal sleep/wake physiology.	Thomas AM , et al. 2016	27692059
Additional	Organization of myelinated axons by Caspr and Caspr2 requires the cytoskeletal adapter protein 4.1B.	Horresh I , et al. 2010	20164332
Additional	Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficits.	Peagarikano O , et al. 2011	21962519
Additional	Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism.	Peagarikano O , et al. 2015	25609168
Additional	Cerebellar associative sensory learning defects in five mouse autism models.	Kloth AD , et al. 2015	26158416
Additional	Comprehensive Analysis of the 16p11.2 Deletion and Null Cntnap2 Mouse Models of Autism Spectrum Disorder.	Brunner D , et al. 2015	26273832
Additional	Cntnap2 knockout rats and mice exhibit epileptiform activity and abnormal sleep/wake physiology.	Thomas AM , et al. 2016	27692059
Additional	Sex-specific gene-environment interactions underlying ASD-like behaviors.	Schaafsma SM , et al. 2017	28115688
Additional	Modulation of prefrontal cortex excitation/inhibition balance rescues social behavior in CNTNAP2-deficient mice.	Selimbeyoglu A , et al. 2017	28768803
Additional	CNTNAP2 stabilizes interneuron dendritic arbors through CASK.	Gao R , et al. 2018	29610457
Additional	Altered Auditory Processing, Filtering, and Reactivity in the Cntnap2 Knock-Out Rat Model for Neurodevelopmental Disorders.	Scott KE , et al. 2018	30126973
Additional	Increased Excitation-Inhibition Ratio Stabilizes Synapse and Circuit Excitability in Four Autism Mouse Models.	Antoine MW , et al. 2019	30679017
Additional	Targeting Peripheral Somatosensory Neurons to Improve Tactile-Related Phenotypes in ASD Models.	Orefice LL , et al. 2019	31398341
Additional	IL-17a Promotes Sociability in Mouse Models of Neurodevelopmental Disorders		31853066
Additional	Tau Reduction Prevents Key Features of Autism in Mouse Models	Tai C et al. 2020	32126198
Additional	Autism spectrum disorder-like behavior caused by reduced excitatory synaptic transmission in pyramidal neurons of mouse prefrontal cortex	Sacai H et al. 2020	33046712
Additional	Dissecting the contribution of host genetics and the microbiome in complex behaviors	Buffington SA et al. 2021	33705688
Additional	Oxytocin normalizes altered circuit connectivity for social rescue of the Cntnap2 knockout mouse	Choe KY et al. 2022	34932941
Additional	Somatosensory cortex hyperconnectivity and impaired whisker-dependent responses in Cntnap2 -/- mice	Balasco L et al. 2022	35483565
Additional		Tripathi MK et al. 2023	37212048
Additional	NA	NA NA	38027494
Additional		et al.	38424048

Various Models
	M_CNTNAP2_10_KI_HT Orefice LL , et al. 2019	M_CNTNAP2_10_KI_HT_ISOGUVACINE Orefice LL , et al. 2019	M_CNTNAP2_11_KD Sacai H et al. 2020	M_CNTNAP2_11_KD_CX-546 Sacai H et al. 2020	M_CNTNAP2_11_KO_HM Choe KY et al. 2022
	M_CNTNAP2_11_KO_HM_chETA Choe KY et al. 2022	M_CNTNAP2_11_KO_HM_OXT Choe KY et al. 2022	M_CNTNAP2_11_KO_HM_TGOT Choe KY et al. 2022	M_CNTNAP2_12_KI_HT_I1253T et al.	M_CNTNAP2_12_KI_HT_I1253T_C79 et al.
	M_CNTNAP2_1_KO_HM Poliak S , et al. 2003	M_CNTNAP2_2_KO_HM Horresh I , et al. 2010	M_CNTNAP2_2_KO_HM_HCNTNAP2 Horresh I , et al. 2010	M_CNTNAP2_3_KO_HM_HCNTNAP2D4.1 Horresh I , et al. 2010	M_CNTNAP2_5_KO_HM et al. NA NA Tripathi MK et al. 2023 Balasco L et al. 2022 Tai C et al. 2020 Antoine MW , et al. 2019 Gao R , et al. 2018 Selimbeyoglu A , et al. 2017 Schaafsma SM , et al. 2017 Thomas AM , et al. 2016 Brunner D , et al. 2015 Kloth AD , et al. 2015 Peagarikano O , et al. 2015 Peagarikano O , et al. 2011
	M_CNTNAP2_5_KO_HM_7-NITROINDAZOLE Tripathi MK et al. 2023	M_CNTNAP2_5_KO_HM_AVP-1 Peagarikano O , et al. 2015	M_CNTNAP2_5_KO_HM_AVP-2 Peagarikano O , et al. 2015	M_CNTNAP2_5_KO_HM_AVP-OXTR-ANT Peagarikano O , et al. 2015	M_CNTNAP2_5_KO_HM_AVPR-ANT_AVP Peagarikano O , et al. 2015
	M_CNTNAP2_5_KO_HM_BH4 Buffington SA et al. 2021	M_CNTNAP2_5_KO_HM_C79 et al.	M_CNTNAP2_5_KO_HM_COCAINE Buffington SA et al. 2021	M_CNTNAP2_5_KO_HM_COHOUSING Buffington SA et al. 2021	M_CNTNAP2_5_KO_HM_DREADD-OXTN Peagarikano O , et al. 2015
	M_CNTNAP2_5_KO_HM_FENOBAM Peagarikano O , et al. 2015	M_CNTNAP2_5_KO_HM_FLUMAZENIL Peagarikano O , et al. 2015	M_CNTNAP2_5_KO_HM_FLUOXETINE Peagarikano O , et al. 2015	M_CNTNAP2_5_KO_HM_GUT Buffington SA et al. 2021	M_CNTNAP2_5_KO_HM_HET_BREEDING Buffington SA et al. 2021
	M_CNTNAP2_5_KO_HM_IL17A-S1DZ	M_CNTNAP2_5_KO_HM_LPS	M_CNTNAP2_5_KO_HM_LREUTERI Buffington SA et al. 2021	M_CNTNAP2_5_KO_HM_MC4R-AG Peagarikano O , et al. 2015	M_CNTNAP2_5_KO_HM_MC4R-AG-OXTR-ANT Peagarikano O , et al. 2015
	M_CNTNAP2_5_KO_HM_OXT-OXTR-ANT Peagarikano O , et al. 2015	M_CNTNAP2_5_KO_HM_OXTR-ANT_AVP Peagarikano O , et al. 2015	M_CNTNAP2_5_KO_HM_OXTR-ANT_MC4R-AG Peagarikano O , et al. 2015	M_CNTNAP2_5_KO_HM_OXTR-ANT_OXT Peagarikano O , et al. 2015	M_CNTNAP2_5_KO_HM_OXYTOCIN Buffington SA et al. 2021
	M_CNTNAP2_5_KO_HM_OXYTOCIN-1 Peagarikano O , et al. 2015	M_CNTNAP2_5_KO_HM_OXYTOCIN-2 Peagarikano O , et al. 2015	M_CNTNAP2_5_KO_HM_OXYTOCIN-3 Peagarikano O , et al. 2015	M_CNTNAP2_5_KO_HM_PV Selimbeyoglu A , et al. 2017	M_CNTNAP2_5_KO_HM_PY Selimbeyoglu A , et al. 2017
	M_CNTNAP2_5_KO_HM_RISPERIDONE Peagarikano O , et al. 2011	M_CNTNAP2_5_KO_HM_S1DZ-INACT	M_CNTNAP2_5_KO_HM_TAU-DEF-1 Tai C et al. 2020	M_CNTNAP2_5_KO_HM_TAU-DEF-2 Tai C et al. 2020	M_CNTNAP2_5_KO_HM_WT-LITTER-SEPARATION Buffington SA et al. 2021
	M_CNTNAP2_6_KO_HT Antoine MW , et al. 2019 Kloth AD , et al. 2015 Peagarikano O , et al. 2011	M_CNTNAP2_7_KO_HM_LPS Schaafsma SM , et al. 2017	M_CNTNAP2_9_KO_HM_MIA Schaafsma SM , et al. 2017	R_CNTNAP2_1_KO_HM Thomas AM , et al. 2016


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contactin associated protein-like 2

contactin associated protein-like 2