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Animal Model >> Cntnap2 Details |
contactin associated protein-like 2
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Summary |
Gene Symbol |
Cntnap2 |
Gene Name |
contactin associated protein-like 2 |
Aliases |
5430425M22Rik, Caspr2, mKIAA0868 |
Model Species |
Mus musculus |
Model Type |
Genetic |
Model Summary |
Axon-glia interactions mediated by Cntnap2 and Tag-1 s allow myelinating glial cells to organize ion channels in the underlying axonal membrane. |
Number of Reports |
22 |
Number of Models |
54 |
External Links |
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ASD-associated variation model |
ASD |
ASD-associated variation model |
ASD Cortical dysplasia-focal epilepsy, ASD |
ASD-associated variation model |
ASD Cortical dysplasia-focal epilepsy, ASD ASD, Pitt-Hopkins-like syndrome 1 |
Animal Model >> Cntnap2 Details |
contactin associated protein-like 2
|
|
Summary |
Gene Symbol |
Cntnap2 |
Gene Name |
contactin associated protein-like 2 |
Aliases |
|
Model Species |
Rattus norvegicus |
Model Type |
Genetic |
Model Summary |
Cntnap2 knockout rats exhibit severe motor seizures, hyperactivity and increased consolidation of wakefulness and REM sleep. |
Number of Reports |
22 |
Number of Models |
54 |
External Links |
|
ASD-associated variation model |
ASD |
ASD-associated variation model |
ASD Cortical dysplasia-focal epilepsy, ASD |
ASD-associated variation model |
ASD Cortical dysplasia-focal epilepsy, ASD ASD, Pitt-Hopkins-like syndrome 1 |
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References |
Primary |
Juxtaparanodal clustering of Shaker-like K channels in myelinated axons depends on Caspr2 and TAG-1.
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Poliak S , et al. 2003
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12963709 |
Primary |
Cntnap2 knockout rats and mice exhibit epileptiform activity and abnormal sleep/wake physiology.
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Thomas AM , et al. 2016
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27692059 |
Additional |
Organization of myelinated axons by Caspr and Caspr2 requires the cytoskeletal adapter protein 4.1B.
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Horresh I , et al. 2010
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20164332 |
Additional |
Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficits.
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Peagarikano O , et al. 2011
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21962519 |
Additional |
Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism.
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Peagarikano O , et al. 2015
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25609168 |
Additional |
Cerebellar associative sensory learning defects in five mouse autism models.
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Kloth AD , et al. 2015
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26158416 |
Additional |
Comprehensive Analysis of the 16p11.2 Deletion and Null Cntnap2 Mouse Models of Autism Spectrum Disorder.
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Brunner D , et al. 2015
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26273832 |
Additional |
Cntnap2 knockout rats and mice exhibit epileptiform activity and abnormal sleep/wake physiology.
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Thomas AM , et al. 2016
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27692059 |
Additional |
Sex-specific gene-environment interactions underlying ASD-like behaviors.
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Schaafsma SM , et al. 2017
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28115688 |
Additional |
Modulation of prefrontal cortex excitation/inhibition balance rescues social behavior in CNTNAP2-deficient mice.
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Selimbeyoglu A , et al. 2017
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28768803 |
Additional |
CNTNAP2 stabilizes interneuron dendritic arbors through CASK.
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Gao R , et al. 2018
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29610457 |
Additional |
Altered Auditory Processing, Filtering, and Reactivity in the Cntnap2 Knock-Out Rat Model for Neurodevelopmental Disorders.
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Scott KE , et al. 2018
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30126973 |
Additional |
Increased Excitation-Inhibition Ratio Stabilizes Synapse and Circuit Excitability in Four Autism Mouse Models.
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Antoine MW , et al. 2019
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30679017 |
Additional |
Targeting Peripheral Somatosensory Neurons to Improve Tactile-Related Phenotypes in ASD Models.
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Orefice LL , et al. 2019
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31398341 |
Additional |
IL-17a Promotes Sociability in Mouse Models of Neurodevelopmental Disorders
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31853066 |
Additional |
Tau Reduction Prevents Key Features of Autism in Mouse Models
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Tai C et al. 2020
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32126198 |
Additional |
Autism spectrum disorder-like behavior caused by reduced excitatory synaptic transmission in pyramidal neurons of mouse prefrontal cortex
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Sacai H et al. 2020
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33046712 |
Additional |
Dissecting the contribution of host genetics and the microbiome in complex behaviors
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Buffington SA et al. 2021
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33705688 |
Additional |
Oxytocin normalizes altered circuit connectivity for social rescue of the Cntnap2 knockout mouse
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Choe KY et al. 2022
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34932941 |
Additional |
Somatosensory cortex hyperconnectivity and impaired whisker-dependent responses in Cntnap2 -/- mice
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Balasco L et al. 2022
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35483565 |
Additional |
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Tripathi MK et al. 2023
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37212048 |
Additional |
NA
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NA NA
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38027494 |
Additional |
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et al.
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38424048 |
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Various Models |
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M_CNTNAP2_10_KI_HT
Orefice LL , et al. 2019
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M_CNTNAP2_10_KI_HT_ISOGUVACINE
Orefice LL , et al. 2019
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M_CNTNAP2_11_KD
Sacai H et al. 2020
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M_CNTNAP2_11_KD_CX-546
Sacai H et al. 2020
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M_CNTNAP2_11_KO_HM
Choe KY et al. 2022
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M_CNTNAP2_11_KO_HM_chETA
Choe KY et al. 2022
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M_CNTNAP2_11_KO_HM_OXT
Choe KY et al. 2022
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M_CNTNAP2_11_KO_HM_TGOT
Choe KY et al. 2022
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M_CNTNAP2_12_KI_HT_I1253T
et al.
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M_CNTNAP2_12_KI_HT_I1253T_C79
et al.
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M_CNTNAP2_1_KO_HM
Poliak S , et al. 2003
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M_CNTNAP2_2_KO_HM
Horresh I , et al. 2010
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M_CNTNAP2_2_KO_HM_HCNTNAP2
Horresh I , et al. 2010
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M_CNTNAP2_3_KO_HM_HCNTNAP2D4.1
Horresh I , et al. 2010
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M_CNTNAP2_5_KO_HM
et al.
NA NA
Tripathi MK et al. 2023
Balasco L et al. 2022
Tai C et al. 2020
Antoine MW , et al. 2019
Gao R , et al. 2018
Selimbeyoglu A , et al. 2017
Schaafsma SM , et al. 2017
Thomas AM , et al. 2016
Brunner D , et al. 2015
Kloth AD , et al. 2015
Peagarikano O , et al. 2015
Peagarikano O , et al. 2011
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M_CNTNAP2_5_KO_HM_7-NITROINDAZOLE
Tripathi MK et al. 2023
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M_CNTNAP2_5_KO_HM_AVP-1
Peagarikano O , et al. 2015
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M_CNTNAP2_5_KO_HM_AVP-2
Peagarikano O , et al. 2015
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M_CNTNAP2_5_KO_HM_AVP-OXTR-ANT
Peagarikano O , et al. 2015
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M_CNTNAP2_5_KO_HM_AVPR-ANT_AVP
Peagarikano O , et al. 2015
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M_CNTNAP2_5_KO_HM_BH4
Buffington SA et al. 2021
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M_CNTNAP2_5_KO_HM_C79
et al.
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M_CNTNAP2_5_KO_HM_COCAINE
Buffington SA et al. 2021
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M_CNTNAP2_5_KO_HM_COHOUSING
Buffington SA et al. 2021
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M_CNTNAP2_5_KO_HM_DREADD-OXTN
Peagarikano O , et al. 2015
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M_CNTNAP2_5_KO_HM_FENOBAM
Peagarikano O , et al. 2015
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M_CNTNAP2_5_KO_HM_FLUMAZENIL
Peagarikano O , et al. 2015
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M_CNTNAP2_5_KO_HM_FLUOXETINE
Peagarikano O , et al. 2015
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M_CNTNAP2_5_KO_HM_GUT
Buffington SA et al. 2021
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M_CNTNAP2_5_KO_HM_HET_BREEDING
Buffington SA et al. 2021
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M_CNTNAP2_5_KO_HM_IL17A-S1DZ
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M_CNTNAP2_5_KO_HM_LPS
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M_CNTNAP2_5_KO_HM_LREUTERI
Buffington SA et al. 2021
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M_CNTNAP2_5_KO_HM_MC4R-AG
Peagarikano O , et al. 2015
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M_CNTNAP2_5_KO_HM_MC4R-AG-OXTR-ANT
Peagarikano O , et al. 2015
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M_CNTNAP2_5_KO_HM_OXT-OXTR-ANT
Peagarikano O , et al. 2015
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M_CNTNAP2_5_KO_HM_OXTR-ANT_AVP
Peagarikano O , et al. 2015
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M_CNTNAP2_5_KO_HM_OXTR-ANT_MC4R-AG
Peagarikano O , et al. 2015
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M_CNTNAP2_5_KO_HM_OXTR-ANT_OXT
Peagarikano O , et al. 2015
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M_CNTNAP2_5_KO_HM_OXYTOCIN
Buffington SA et al. 2021
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M_CNTNAP2_5_KO_HM_OXYTOCIN-1
Peagarikano O , et al. 2015
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M_CNTNAP2_5_KO_HM_OXYTOCIN-2
Peagarikano O , et al. 2015
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M_CNTNAP2_5_KO_HM_OXYTOCIN-3
Peagarikano O , et al. 2015
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M_CNTNAP2_5_KO_HM_PV
Selimbeyoglu A , et al. 2017
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M_CNTNAP2_5_KO_HM_PY
Selimbeyoglu A , et al. 2017
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M_CNTNAP2_5_KO_HM_RISPERIDONE
Peagarikano O , et al. 2011
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M_CNTNAP2_5_KO_HM_S1DZ-INACT
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M_CNTNAP2_5_KO_HM_TAU-DEF-1
Tai C et al. 2020
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M_CNTNAP2_5_KO_HM_TAU-DEF-2
Tai C et al. 2020
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M_CNTNAP2_5_KO_HM_WT-LITTER-SEPARATION
Buffington SA et al. 2021
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M_CNTNAP2_6_KO_HT
Antoine MW , et al. 2019
Kloth AD , et al. 2015
Peagarikano O , et al. 2011
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M_CNTNAP2_7_KO_HM_LPS
Schaafsma SM , et al. 2017
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M_CNTNAP2_9_KO_HM_MIA
Schaafsma SM , et al. 2017
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R_CNTNAP2_1_KO_HM
Thomas AM , et al. 2016
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HELP
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